Graham Wallace

Birmingham and Midland Eye Centre, Birmingham, UK.

JOURNAL REVIEWED: Experimental Eye Research

Latest Contribution

CD40L activation of human RPE cells

1 August 2018 | | Retina / Uvea / Vitreous | AMD, Age-related macular degeneration, CD40L, IL-1β, Inflammasome, MCP-1, RPE, Retinal pigment epithelium

Age-related macular degeneration (AMD) is the leading cause of reduced visual acuity in the elderly worldwide. The risk factors involved in AMD include smoking and diet, while genetics have been shown to have a significant role. Recently a link between...

ABCA1 mediates lipid efflux in the retina

1 June 2018 | | Retina / Uvea / Vitreous | ABCA1, ApoA-I, Cholesterol efflux, HDL, LXR, RPE

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. There are two forms of AMD, dry and wet, the latter so named because of the presence of choroidal neovascularisation. Both forms lead to retinal pigment...

ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy

1 June 2018 | | Retina / Uvea / Vitreous | Adipocytokine, Angiopoietin-like protein-4 (ANGPTL-4), Diabetic retinopathy (DR), Hypoxia inducible factor-1 alpha (HIF-1α), Inflammation, Profilin-1

Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...