Inner nuclear layer of the retina showing increase in thickness in diabetic macular oedema
1 October 2015
| Bheemanagouda Patil
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Retina / Uvea / Vitreous
Diabetic retinopathy is one of the leading causes of blindness in the developed world. With optical coherence tomography (OCT), it has become possible to image the retina in vivo and to measure retinal oedema by measuring retinal thickness (RT) with...
Myopic choroidal neovascularisation
1 August 2015
| Jonathan Chan
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Retina / Uvea / Vitreous
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Neovascularisation, Retina, Treatment Medical
This is a review article summarising the latest myopic CNV (choroidal neovascularisation) literature in the clinical experience and management outcomes for recommendation algorithm. The aetiology of the myopic CNV was discussed by the authors under the heading of the heredo-degenerative...
Choroidal and RNFL thickness in patients with OSAS
1 August 2015
| Anjali Gupta
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Retina / Uvea / Vitreous
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choroidal thickness, obstructive sleep apnoea syndrome, spectral-domain optical coherence tomography
In obstructive sleep apnoea syndrome (OSAS), hypoxia secondary to repetitive apnoeic episodes leads to blood pressure variations and haemodynamic changes. There is also intermittent activation of the sympathetic system when the patient is aroused from sleep during apnoeic episodes. OSAS...
Air toxicity on retinal pigment epithelium
1 August 2015
| Khadijah Basheer
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Retina / Uvea / Vitreous
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Air toxicity, internal gas tamponade, pars plana vitrectomy, pneumoretinopexy, retinal pigment epithelium
This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...
Transfected RPE cells inhibit AMD in rats
1 August 2015
| Graham Wallace
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Choroidal neovascularization, Fibulin-5, Retinal pigment epithelium, Transplantation
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...
Persistence of Ebola virus in ocular fluid during convalescence
1 August 2015
| Jonathan CP Roos
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Retina / Uvea / Vitreous
The most recent Ebola outbreak has infected over 26,300 patients, but also resulted in the highest number of survivors in history. Uveitis has been described during the convalescent period, but Varkey and colleagues report, for the first time, finding viable...
Stereotactic radiotherapy for polypoidal choroidal vasculopathy
1 August 2015
| Sofia Rokerya
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Retina / Uvea / Vitreous
Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular AMD. It is a disease of choroidal vasculature characterised by abnormal branching vascular network with aneurysmal dilatations (polyps). Features of PCV include pigment epithelial detachments (PED), subretinal fluid (SRF) accumulation and...
Outcomes of ‘treat and extend’ for neovascular AMD
1 August 2015
| Brian Ang
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Retina / Uvea / Vitreous
The authors report on 24-month outcomes of anti-vascular endothelial growth factor (anti-VEGF) therapy using a ‘treat and extend’ regime for treatment-naïve neovascular age-related macular degeneration (nAMD). Data for this study was collected from the Fight Retinal Blindness observational registry based...
Association between smoking and uveitis
1 August 2015
| Brian Ang
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Retina / Uvea / Vitreous
This is a retrospective, population-based, case-control study from the general Kaiser Hawaii population. Over a two year period (1 January 2006 to 31 December 2007), there were 100 confirmed incident cases of uveitis. Two control groups were created, with 522...
Effect of anti-VEGF treatment on PED morphology
1 June 2015
| Jaya Myneni
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Retina / Uvea / Vitreous
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Choroidal neovascularization, optical coherence tomography, ranibizumab, VEGF
This retrospective study of 30 eyes assessed the effect of anti-VEGF on morphology of pigment epithelial detachments (PED) secondary to age-related macular degeneration (AMD). Thirty eyes of 28 patients with PED were compared to 30 eyes of 30 patients with...
Does paediatric uveitis reactivate after treatment with anti-TNF-a drugs?
1 June 2015
| Efrosini Papagiannuli
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Retina / Uvea / Vitreous
As a potentially blinding disease that can affect 7-27/100000 children, uveitis remains a rare condition, where little evidence based data is available to guide management decisions. Most paediatric uveitis cases are chronic, anterior and non-infectious and may be associated with...
Endophthalmitis after intravitreal injections in France
1 June 2015
| Efrosini Papagiannuli
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Retina / Uvea / Vitreous
In this nationwide, retrospective, multicentre case series, the authors looked at the incidence and characteristics of endophthalmitis after intravitreal injections of anti-VEGFs and steroids, given for a variety of posterior segment conditions (macular oedema secondary to diabetes or retinal vein...
