Polymerase chain reaction evaluation of infectious multifocal serpiginoid choroiditis
1 December 2014
| Nikolaos D Georgakarakos
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Retina / Uvea / Vitreous
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Chain reaction, infectious, multifocal serpiginoid choroiditis, polymerase, tuberculosis, viral
This paper presents a retrospective review of infectious agents associated with multifocal serpiginous choroiditis (MSC) based on polymerase chain reaction (PCR) evaluation and specific antimicrobial therapy. The study included 13 patients with MSC who were evaluated with PCR for the...
Role of fundus autofluorescence patterns and baseline atrophy area on geographic atrophy progression
1 December 2014
| Bheemanagouda Patil
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Retina / Uvea / Vitreous
Central geographic atrophy (GA) is one of the morphological sub types of late-stage macular degeneration. The natural course of the disease is characterised by expanding areas of macular atrophy, which cause absolute scotoma. Fundus autofluorescence (FAF) is derived from lipofuscin...
Intravitreal functional plasminogen in branch retinal vein occlusion
1 December 2014
| Bheemanagouda Patil
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Retina / Uvea / Vitreous
Branch retinal vein occlusion (BRVO) is the second most common vascular disorder of the eye. Intravitreal injections of anti-VEGF agents and corticosteroids have proven efficacy. Posterior vitreous cortex (PVC) adhesion has been shown to support the development of retinal vein...
Efficacy of intravitreal dexamethasone implant in patients with persistent macular oedema
1 December 2014
| Sofia Rokerya
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Retina / Uvea / Vitreous
Chronic cystoid macular oedema (CME) can develop secondary to various pathologies such as diabetic maculopathy, retinal vein occlusion and uveitis. It can cause significant visual impairment and macular damage. The therapeutic effect of corticosteroids in CME is through one or...
Uveitis in HIV infected persons
1 October 2014
| Anjali Gupta
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Retina / Uvea / Vitreous
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AIDS, HIV, acquired immunodeficiency syndrome, human immunodeficiency virus, uveitis
Before the advent of highly active antiretroviral therapy (HAART), uveitis, in particular cytomegalovirus (CMV) retinitis, was the most common cause of visual loss in patients with AIDS. HAART has altered the cause of ocular disease in HIV infected individuals by...
Ranibizumab versus laser in diabetic macular oedema (LUCIDATE study)
1 October 2014
| Efrosini Papagiannuli
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Retina / Uvea / Vitreous
The aim of this study was to compare the functional and structural effects of Ranibizumab versus macular laser treatment in patients with diabetic macular oedema. It was a single centre, prospective, randomised, single masked clinical trial spanning a 48 week...
The choroid in pregnancy
1 October 2014
| Khadijah Basheer
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Retina / Uvea / Vitreous
During pregnancy there can be different types of ocular changes including a decrease in corneal sensitivity, increase in central corneal thickness and curvature, decrease in intraocular pressure, central serous chorioretinopathy and ocular blood flow. Advances in ophthalmic imaging devices has...
MicroRNA mediate retinoblastoma signal transduction
1 October 2014
| Graham Wallace
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Retina / Uvea / Vitreous
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KEGG, cell migration, colony formation, microRNA-21, phosphorylation signaling pathway, retinoblastoma, seed-targeting, tiny anti-miRNA
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Akimba mice, a model of human diabetic retinopathy
1 October 2014
| Graham Wallace
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Retina / Uvea / Vitreous
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Akimba, BRB, PLVAP, blood-retinal barrier, diabetic macular edema, diabetic retinopathy, mouse models, retina
Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...
B-scan ultrasonography
1 October 2014
| Nana Theodorou
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Retina / Uvea / Vitreous
B-scan ultrasonography is commonly employed for the diagnosis and follow-up of ocular trauma. This retrospective study looked at the accuracy and predictive ability of B-scan ultrasonography following open globe repair. Of the 965 patients identified with open globe injuries at...
Early surgery for epiretinal membrane
1 October 2014
| Nana Theodorou
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Retina / Uvea / Vitreous
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epiretinal membrane, combined phakovitrectomy, OCT
This was a retrospective case review study in 120 consecutive patients with idiopathic epiretinal membrane. The average patient age was 72 years with a mean follow-up of 6.5 months. Inclusion criteria consisted of symptomatic patients with visual acuity of 1.0...
Resolution of mid-peripheral schisis in x-linked retinoschisis with the use of dorzolamide
1 October 2014
| Huw Edward Oliphant
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Retina / Uvea / Vitreous
X-linked retinoschisis (XLRS) is an early onset hereditary retinal dystrophy. It is caused by mutations of the RS1 gene. Common manifestations of XLRS are schitic lesions at the macula, as well as infero-temporal schisis. Carbonic anhydrase inhibitors have previously been...
