Journal Reviews
Factors influencing the outcome of GT and TBT in PCG
This is a retrospective study between 2013 to 2016 of 452 eyes of patients </=12 years with primary congenital glaucoma (PCG), who underwent either goniotomy (GT) (median age: six months, 120 eyes) or trabeculotomy (TBT) (median age: 5.2 months, 332...
Intraocular pressure changes following TOHM washout
This retrospective study between 2008 and 2019 of 110 eyes with primary open angle glaucoma (POAG), 33 eyes with ocular hypertension (OHT) and 43 eyes with uveitic glaucoma (UG) evaluated the changes in intraocular pressure (IOP) following topical ocular hypotensive...
A pulsatile pump in the TM, a new concept in trabecular outflow research
This is a research article where the authors propose a new model in conceptualising the mechanisms involved in the aqueous outflow at the trabecular meshwork (TM). The authors demonstrated evidence of a pump within the Schlemm’s canal. A pulse generated...
The effects of ab-interno XEN gel implantation on postural IOP elevations
The study involved 18 patients with XEN gel implants, 30 patients who had trabeculectomy, and 30 medically managed glaucoma patients. All patients in XEN gel implant and trabeculectomy groups had at least 11 months of follow-up following successful surgery resulting...
Efficacy and safety of novel PF brimonidine / timolol fixed-combination ophthalmic solution for OAG
This study is a multicentre, randomised, open-label, parallel-group clinical trial to evaluate the efficacy and safety of a newly developed preservative-free (PF) brimonidine / timolol fixed-combination (BTFC) ophthalmic solutions as compared with preservative-containing (PC) BTFC ophthalmic solution in adult patients...
Uveitis‐Glaucoma‐Hyphaemia syndrome retrospective case-control study
The authors present the findings of a case-control study aiming to assess uveitis‐glaucoma‐hyphaemia (UGH) syndrome, focusing on the resolution, glaucoma development and risk factors. The authors compared three groups each containing 71 patients. Each group contained patients with UGH syndrome,...
SLT versus medication for OAG
This paper appraised existing randomised clinical trials (RCTs), which compared selective laser tabeculoplasty (SLT) with medical therapy for open-angle glaucoma (OAG), and performed a systematic review and meta-analysis. A total of 1229 patients in eight trials were included from PubMed,...
Effect of trabeculectomy on corneal endothelial cell loss
This is a prospective study of 117 eyes for two years after trabeculectomy, to investigate the corneal endothelial cell density (CECD) by specular microscopy prior to and after surgery on a six monthly basis. At six, 12, 18 and 24...
Effect of caffeine and low intensity endurance exercise on intraocular pressure
This placebo controlled, double blind, balanced crossover study reports in healthy individuals that 30 minutes of cycling caused a maximum of 2.7mmHg lowering of IOP. A caffeine dose of 4mg/kg 30 minutes prior to cycling negated this effect. The conclusion...
Visual field progression after glaucoma drainage device implantation
This retrospective interventional case series assessed changes to visual fields after implantation of a glaucoma drainage device (Baerveldt, Ahmed or Molteno Devices) between 2010 and 2015. A total of 106 eyes from 96 patients were included in the final analysis...
Glaucoma screening in primary care and community settings
Glaucoma is one of the most common causes of irreversible blindness in the United States due to its insidious progression and diagnosis in late stages. The cost-effectiveness of screening for glaucoma has been debated, and screening of high-risk groups for...
Trab360: surgical management of childhood glaucoma
This multicentre retrospective interventional case series reports the outcomes and complications of trabeculotomy ab interno using the Trab360 device in childhood glaucoma’s. Forty-six eyes of 41 patients were included and had a mean follow-up of 14.5 months. Mean preoperative intraocular...
