Dilate or not in subconjunctival haemorrhage?
There is often surprisingly little evidence in common clinical conditions. Spontaneous non-traumatic subconjunctival haemorrhage (SCH) is frequently encountered in emergency and walk-in clinic visits. In some centres, a dilated fundus exam is performed to exclude retinal pathology. This retrospective study...
Keratoconus cone variants
This retrospective study examined correlation between three keratoconic parameters to further understand anatomy of keratoconic cones. Kmax and pachymetry of the thinnest point were obtained from the Pentacam scans. Decentration was calculated as distance from the corneal vertex to the...
Femto-DMEK – a solution for high re-bubbling rates?
This retrospective study examined results of patients that underwent femtosecond laser enabled descemet membrane endothelial keratoplasty (DMEK) (FE-DMEK) and manual DMEK (M-DMEK) for Fuch’s endothelial dystrophy. In FE-DMEK femtosecond laser was used to create 8.25mm descemetorhexis, whereas during M-DMEK- descemetorhexis...
Keratolimbal allograft and tumour transmission
This case report describes tumour transmission from keratolimbal allograft donor to recipient. A 68-year-old woman underwent keratolimbal allograft (KLAL) for limbal stem cell failure from a donor, who died of invasive breast carcinoma that had metastasised to multiple levels of...
What about the children? Cornea cross-linking for children with keratoconus
1 October 2017
| Eulee Seow
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EYE - Cornea, EYE - General
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cornea, cross-linking, keratoconus, paediatric
Keratoconus can behave more aggressively in paediatric than in adult patients. Collagen cross-linking has been shown to slow the progression of keratoconus in adults. This systematic review determined the effectiveness of corneal collagen cross-linking (CXL) in children. For this study,...
Clinical outcomes of AMT in acute ocular chemical injury
1 August 2017
| Jonathan Chan
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EYE - Cornea, EYE - General
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Cornea, Inflammation, Ocular surface, Stem Cells, Treatment Surgery
This is a retrospective study of patients from two units in Germany and UK between 1998 and 2008. The ocular chemical burns were classified by Roper-Hall and Dua classifications. A total of 72 eyes of 54 patients aged 37.3 years...
DSEK – five year results
This UK based study examined long-term descemet stripping endothelial keratoplasty (DSEK) results, looking at graft survival and endothelial cell losses. Data on 210 grafts were included in analysis. Most frequent indication for DSEK was Fuch’s endothelial dystrophy (81.4%) and 46.3%...
Silent keratitis in failed graft
This study examined rates of asymptomatic keratitis in failed full thickness corneal grafts, which were not picked up clinically preoperatively. During a five year period 53 penetrating keratoplasties (PK) were performed for long-standing graft decompensation with stromal opacity and /...
Stromal cell alignment in damaged cornea
1 August 2017
| Graham Wallace
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EYE - Cornea, EYE - General
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Confocal microscopy, Corneal wound healing, Extracellular matrix, SHG imaging
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...
Does Acanthamoeba need bacteria to cause keratitis?
An animal study was carried out on 36 rabbits, whose corneas were inoculated with either Acanthamoeba castellanii alone, Pseudomonas aeruginosa alone or both pathogens together after a period of short (two hours) or long (six hours) co-incubation. The clinical severity...
Risk factors for DSEAK graft detachment
This was a retrospective data review on all patients who underwent primary descemet stripping automated endothelial keratoplasty (DSEAK) during a 10 year period: 1212 eyes were included in the analysis. Postoperative graft detachment occurred in 45 eyes (3.7%) and required...
Corneal lenticule allotransplant
This animal study looked at corneal lenticule allograft transplantation in rabbits. Seven rabbits underwent small incision lenticule extraction (SMILE) procedures, where their stromal lenticules were extracted and transplanted fresh into pre-prepared corneal stromal pockets of seven recipient eyes. Animals were...
