Do occult neuroretinitis and non-arteritic anterior ischaemic optic neuropathy differ in presentation?
6 February 2024
| Claire Howard
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EYE - Neuro-ophthalmology
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Occult, differentiating, neuroretinitis, non-arteritic anterior ischaemic optic neuropathy, optical coherence tomography
This study evaluates differences between neuroretinitis and non-arteritic anterior ischaemic optic neuropathy (NAAION) in terms of patient demographics, clinical presentation, and optical coherence tomography (OCT) findings. Medical records of patients with a final diagnosis of occult neuroretinitis or NAAION were...
Rare presentation of giant cell arteritis in Chinese subjects
1 September 2023
| Claire Howard
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EYE - Neuro-ophthalmology
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non-arteritic anterior ischaemic optic neuropathy, Chinese, central retinal artery occlusion, Giant cell arteritis, ocular ischaemic syndrome, posterior ischaemic optic neuropathy
Only a few case reports of biopsy-proven GCA (BpGCA)-associated vision loss in Chinese subjects have been published. This paper presents three elderly Chinese subjects with BpGCA who presented with vision loss. A search of the literature was also conducted to...
Can coenzyme Q10 have a protective role in ethambutol-induced retinal ganglion cell toxicity
3 April 2023
| Claire Howard
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EYE - Neuro-ophthalmology
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Ethambutol, coenzyme Q10, ethambutol toxic optic neuropathy, retinal ganglion cells, tuberculosis
Tuberculosis (TB) is one of the most prevalent infectious diseases, especially in developing or low- income countries. Ethambutol is a widely used drug to treat TB. Ethambutol can cause visual disturbance including ethambutol toxic optic neuropathy (ETON). ETON is one...
Visual prognosis in Irish Leber’s hereditary optic neuropathy
1 December 2022
| Claire Howard
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EYE - Neuro-ophthalmology
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Leber’s hereditary optic neuropathy, idebenone, inherited optic neuropathy, mtDNA, ophthalmic genetics, optic atrophy
Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...
G-CSF intravitreal injections for NAION: a pilot study
5 April 2022
| Su Young
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EYE - Neuro-ophthalmology
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Anterior ischemic optic neuropathy, Granulocyte colony-stimulating factor, Intravitreal injection, Neuroprotection, Optic atrophy
In rodent models with anterior ischemic optic neuropathy (AION), granulocyte colony-stimulating factor (G-CSF) confers a neuroprotective effect on retinal ganglion cells (RGCs) via anti-apoptotic and anti-inflammatory processes. This prospective study investigated the efficacy of intravitreal injection of G-CSF for the...
A retrospective medical notes review in patients with poor vision due to NAION
1 December 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Non-arteritic anterior ischaemic optic neuropathy, NAION, severe visual loss, visual acuity
Very severe visual loss (hand movements or less) is typical of arteritic anterior ischaemic optic neuropathy (AION) and relatively rare in non-arteritic AION (NAION). This study aimed to report the frequency of very poor visual acuity (VA) in NAION. The...
Unusual case presentation of arteritic anterior ischaemic optic neuropathy
1 December 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Arteritic anterior ischaemic, optic neuropathy, polyangiitis overlap syndrome
The authors present a single case of an 84-year-old man with arteritic anterior ischaemic optic neuropathy, but with unusual features on temporal artery biopsy. He presented with a three-day history of sudden onset of loss of vision in his right...
Unique case of steroid-induced intraocular pressure spike causing NAION
7 April 2021
| Annes Ahmeidat
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EYE - Neuro-ophthalmology
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Herpes zoster, Intraocular pressure, Ischemic optic neuropathy, NAION
The literature describes previous cases of nonarteritic anterior ischaemic optic neuropathy (NAION) following rapid rises in intraocular pressure (IOP) leading to reduced optic nerve head perfusion and disruption. This is commonly following ophthalmic procedures, acute glaucoma or steroid eye drops....
A novel way to distinguish between types of anterior ischaemic optic neuropathy
7 April 2021
| Claire Howard
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EYE - Neuro-ophthalmology
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Anterior ischaemic optic neuropathy, inflammation, monocyte to high-density lipoprotein ratio
The authors evaluate the monocyte to high-density lipoprotein (HDL) ratio (MHR) in patients with arteritic and non arteritic anterior ischaemic optic neuropathy (A-AION / NA-AION). A distinction between the two types of AION is essential to begin appropriate treatment, which...
A novel way to diagnose optic neuropathies using Bruch’s membrane opening
7 December 2020
| Claire Howard
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EYE - Neuro-ophthalmology
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Glaucomatous neuropathy, compressive optic neuropathy, minimal rim width, non-arteritic anterior ischaemic optic neuropathy, non-glaucomatous neuropathy
Differential diagnosis of optic neuropathies can be challenging but is crucial for the correct management of the underlying disease and prevention of further damage. Bruch’s membrane opening (BMO) was recently discovered as the anatomical border of the optic disc. BMO...
Investigation of blood platelet parameters in anterior ischaemic optic neuropathy
1 August 2019
| Claire Howard
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EYE - Neuro-ophthalmology
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Anterior ischemic optic neuropathy, mean platelet volume, neutrophil to lymphocyte ratio, platelet distribution width, plateletcrit
The aim of this clinical retrospective comparative study was to assess the possible relationship between arteritic anterior ischaemic optic neuropathy (AAION) and non-arteritic anterior ischaemic optic neuropathy (NAION) with blood platelet parameters and neutrophil-to-lymphocyte ratio (NLR). The medical records of...
Paraneoplastic optic neuropathy features
1 August 2019
| Jonathan Chan
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EYE - Neuro-ophthalmology
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PNS antibodies, paraneoplastic optic neuropathy, paraneoplastic syndrome (PNS)
This is a retrospective review of seven patients diagnosed with paraneoplastic optic neuropathy (PON) between January 2015 and June 2017. Five patients had a history of primary malignancy, including papillary thyroid carcinoma, type B thymoma, testicular seminoma and lung carcinoma....
