OCT biomarkers in asymmetric anti-VEGF response in bilateral diabetic macular oedema
1 December 2021
| Su Young
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Retina / Uvea / Vitreous
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Diabetic macular edema, aflibercept, optical coherence tomography, predictive, ranibizumab
This study aimed to identify optical coherence tomography (OCT) biomarkers for predicting response to anti-VEGF treatment in diabetic macular oedema (DMO). Bilateral DMO patients with asymmetric response to a loading dose of anti-VEGF (ranibizumab / aflibercept) treatment were retrospectively studied....
Outcomes of treat & extend ranibizumab in diabetic macular oedema
1 October 2021
| Ed Rule
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Retina / Uvea / Vitreous
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Diabetic macular edema, Outcome predictor, Ranibizumab, Spectral-domain optical coherence tomography, Treat and extend
This study retrospectively evaluated 118 eyes of 87 patients who received ranibizumab in a treat and extend regimen for diabetic macular oedema (DMO). Data were collected for patients under follow-up for 24 months. After 24 months, patients gained a mean...
Steroid treatment for pseudophakic cystoid macular oedema
1 October 2021
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
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Cystoid macular edema, intravitreal steroids, triamcinolone
The authors present a retrospective comparison of 45 eyes of 41 patients treated with 2mg intravitreal triamcinolone (IVT group) and 50 eyes of 42 patients treated with 40mg sub-Tenons triamcinolone (STT group) for pseudophakic cystoid macular oedema (CMO). The visual...
Transient macular thinning with Densiron 68
4 August 2021
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
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OCT, Retinal detachment, heavy silicone oil, macula
Densiron 68 is a heavy silicone oil (HSO) used to treat rhegmatogenous retinal detachments (RRD) with inferior retinal breaks. The authors compared changes in retinal thickness during and after the use of Densiron endotamponade, and looked at any association between...
The effects of anti-VEGF therapy for NvAMD on retinal vasculature
4 August 2021
| Su Young
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Retina / Uvea / Vitreous
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aflibercept, foveal avascular zone, neovascular age-related macular degeneration, ranibizumab, retinal vessel density
This retrospective consecutive case series examined 54 eyes of 54 treatment-naïve neovascular age-related macular degeneration (N-AMD) patients. Thirty-three eyes received intravitreal aflibercept injections, and 21 eyes received intravitreal ranibizumab injections with unaffected fellow eyes (54 eyes) as controls. All image...
OCTA in geographic atrophy
4 August 2021
| Sofia Rokerya
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Angiography, Choriocapillaris, Choroid, Optical coherence tomography
In this article the authors aim to give an overview of the current literature concerning the application of OCT-A in geographic atrophy (GA). GA is a disease characterised by loss of outer retinal layers including photoreceptors, degeneration of the retinal...
Wet AMD outcomes post cataract surgery
3 June 2021
| Kareem Waleed Alsaffarini
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EYE - Cataract, EYE - Refractive
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age-related cataract, antivascular endothelial growth factor, cataract surgery, wet age-related macular degeneration
The authors present the findings of a retrospective study looking at the progression of wet age-related macular degeneration (AMD) in patients who underwent cataract surgery. They recruited a series of 111 patients of which 38 were men and 73 were...
Characteristics of Charles Bonnet syndrome in patients with neovascular AMD
7 April 2021
| Ed Rule
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Charles Bonnet syndrome, Low vision, Negative outcome, Visual hallucinations
This retrospective cross-sectional study aimed to characterise various aspects of Charles Bonnet syndrome hallucinations among patients with neovascular age-related macular degeneration (AMD). Five hundred and ten consecutive patients were asked a screening question to determine if they had ever suffered...
Changes in drusen and retinal layer volumes prior to CNV development
7 April 2021
| Ed Rule
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Choroidal neovascularisation type, Drusen load, Imaging biomarkers, Retinal layer volumes
This retrospective longitudinal study looked at patients with wet age-related macular degeneration (AMD) in one eye who subsequently developed wet AMD in the fellow eye. The aim was to discover whether drusen characteristics or volumes of retinal layers correlate with...
Effect of blue-light filtering intraocular lenses on age-related macular degeneration
7 April 2021
| Anna Song
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Anti–vascular endothelial growth factor, Blue-light filtering, Cataract surgery, Choroidal neovascularization, Intraocular lens, Neovascular age-related macular degeneration
This is a retrospective cohort study evaluating whether blue-light filtering (BLF) intraocular lenses (IOL) offer prophylaxis for neovascular age-related macular degeneration (nAMD). The study included 11,397 eyes of 11,397 patients with a mean age of 75.4 ±8.3 years that underwent...
Intravitreal Ziv-Aflibercept: safety analysis
7 December 2020
| Su Young
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Retina / Uvea / Vitreous
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Diabetic macular edema (DME), Intravitreal ziv, aflibercept (IVZ), Neovascular age related macular degeneration (n, AMD), Ziv, aflibercept, retinal venous occlusion (RVO)
Ziv-Aflibercept (Zaltrap; Sanofi-Aventis U.S LLS, Bridgewater, NJ) was originally introduced as an intravenous formulation for metastatic colorectal cancer. The adoption of Ziv-Aflibercept in ophthalmic practice was similar to bevacizumab, and reports have previously examined one to two year visual outcomes...
Silicone oil in rhegmatogenous retinal detachment
5 June 2020
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
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Rhegmatogenous retinal detachment, epiretinal membrane, macular edema, optical coherence tomography, silicone oil tamponade
Silicone oil (SO), used in complicated retinal detachments, is associated with complications such as cataract, increased intraocular pressure (IOP), keratopathy, cystoid macular oedema (CMO), epiretinal membrane (ERM) and loss of vision. Emulsification of oil can also lead to migration of...
