Silicone oil in rhegmatogenous retinal detachment
5 June 2020
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
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Rhegmatogenous retinal detachment, epiretinal membrane, macular edema, optical coherence tomography, silicone oil tamponade
Silicone oil (SO), used in complicated retinal detachments, is associated with complications such as cataract, increased intraocular pressure (IOP), keratopathy, cystoid macular oedema (CMO), epiretinal membrane (ERM) and loss of vision. Emulsification of oil can also lead to migration of...
Retinal vessel diameter in pseudoexfoliation
5 February 2020
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
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Retinal vessel diameter, optical coherence tomography, pseudoexfoliation
Pseudoexfolation (PEX) is characterised by deposition of fibrillary extracellular material on ocular and extraocular tissue. Studies have shown that deposition in vascular structures cause hypoxia and ischaemia. In the eye, a decrease in blood supply to the optic nerve can...
Progression of retinitis pigmentosa
2 December 2019
| Ivan Yip
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Retina / Uvea / Vitreous
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fundus autofluorescence, microperimetry, multimodal imaging, disease progression, optical coherence tomography
This retrospective study evaluates the rate of progression of retinitis pigmentosa (RP) using multimodal imaging, including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and microperimtery (MP). Traditional tests used to evaluate RP, for example, Goldmann visual fields and ERG...
DRIL after macular oedema treatment in BRVO
1 June 2019
| Sofia Rokerya
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Retina / Uvea / Vitreous
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Anti-vascular endothelial growth factor treatment, Branch retinal vein occlusion, Disorganization of the retinal inner layer, Spectral-domain optical coherence tomography, Visual acuity
The authors report the analysis of a single-site, retrospective, cross-sectional study to evaluate the association between disorganisation of the retinal inner layers (DRIL) and visual acuity (VA) after anti-VEGF treatment for macular oedema (MO) due to branch retinal vein occlusion...
An atypical presentation of Vogt-Koyanagi-Harada Disease
1 August 2018
| Claire Howard
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EYE - Neuro-ophthalmology
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Indocyanine green angiography, neuroretinitis, optical coherence tomography, Vogt-Koyanagi-Harada disease
The authors present a single case of atypical presentation of Vogt-Koyanagi-Harada disease. A 42-year-old female presented with unilateral visual loss associated with systemic symptoms of fever and headache. Initial ophthalmic examination revealed a unilateral neuroretinitis, however, investigations for infectious and...
Retinal ganglion cell loss in diabetes and diabetic retinopathy
1 October 2016
| Anjali Gupta
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Retina / Uvea / Vitreous
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diabetes, diabetic retinopathy, neuronal damage, optical coherence tomography, retinal ganglion cell
The aim of this observational case control study was to evaluate the association of diabetes and diabetic retinopathy (DR) with retinal ganglion cell loss. Cases were Chinese patients with type 2 diabetes with and without DR, aged 40-80 years. Eligible...
Retinal changes in Leber hereditary optic neuropathy
1 August 2016
| Claire Howard
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Neuro-Ophthalmology
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Ganglion cell complex, Leber hereditary optic neuropathy, optical coherence tomography, retinal nerve fibre layer
The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time, in patients with Leber’s hereditary optic neuropathy (LHON). For this study, 21 patients...
Using OCT to screen and monitor Alzheimer’s disease
1 June 2016
| Claire Howard
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Neuro-Ophthalmology
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Macular thickness, mild cognitive impairment, optical coherence tomography, subjective memory complaints
Alzheimer’s disease (AD) is a neurodegenerative illness characterised by progressive decline in cognitive function. AD is the main cause of dementia worldwide. Over recent years researchers have strived to find biomarkers to diagnose AD, particularly in the early stages of...
Comparison of central laminar thickness in optic neuropathy and normal eyes
1 February 2016
| Claire Howard
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Oculoplastics, Orbit
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Enhanced depth imaging optical coherence tomography, glaucomatous optic neuropathy, lamina cribrosa, non-glaucomatous optic neuropathy
The study compares central laminar thickness (LT) among patients with glaucomatous optic neuropathy (GON), patients with non-GON and normal subjects. The non-GON group comprised eyes with demyelinating optic neuropathy (ON), anterior ischaemic ON, compressive ON, Leber hereditary ON and traumatic...
Visual outcomes, visual fields and optical coherence tomography in paediatric craniopharyngioma
1 October 2015
| Claire Howard
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Neuro-Ophthalmology
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Craniopharyngioma, ganglion cell colour map, optical coherence tomography, optic neuropathy children, visual field
This study reviews the visual outcomes of ten patients under the age of 18 years with craniopharyngioma. The paper also reviews the correlation between visual field (VF) testing and optical coherence tomography (OCT) examination and evaluates the role of OCT...
Choroidal and RNFL thickness in patients with OSAS
1 August 2015
| Anjali Gupta
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Retina / Uvea / Vitreous
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choroidal thickness, obstructive sleep apnoea syndrome, spectral-domain optical coherence tomography
In obstructive sleep apnoea syndrome (OSAS), hypoxia secondary to repetitive apnoeic episodes leads to blood pressure variations and haemodynamic changes. There is also intermittent activation of the sympathetic system when the patient is aroused from sleep during apnoeic episodes. OSAS...
Structural effects of migraine on the retina
1 June 2015
| Claire Howard
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Neuro-Ophthalmology
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Migraine, retinal nerve fibre layer thickness, spectral-domain optical coherence tomography
Migraine is a common, chronic, multifactorial neuro-vascular disorder typically characterised by recurrent attacks of disabling headache and autonomic nervous system dysfunction (migraine without aura). Up to one third of patients also have neurological aura symptoms (migraine with aura). The objective...
