Journal Reviews
Pupil responses in diabetes
This study aimed to investigate pupillary involvement in patients with type 2 diabetes mellitus (DM) and to evaluate any relationship between severity of diabetic retinopathy (DR) and pupillary responses. Participants included 133 individuals in four groups: proliferative DR (n=21), non-proliferative...
Efficacy of IVC injection in the treatment of ROP
This is a retrospective consecutive case series of patients who received intravitreal conbercept (IVC) as a primary treatment from June 2015 to July 2016 for treatment of retinopathy of prematurity (ROP). Forty-eight eyes of 24 patients were included in the...
Control of bleeding with diabetic vitrectomy under air
The authors describe a modified diabetic vitrectomy using continuous air infusion in diabetic eyes with severe fibrovascular proliferation. In their case series of 25 eyes (20 patients), intravitreal bevacizumab (1.25mg) was used one week prior to surgery. Fifteen eyes had...
Two illustrative cases of AZOOR
The authors present two illustrative cases of acute zonal occult outer retinopathy (AZOOR) which causes acute idiopathic blind spot enlargement. The disease is characterised by sudden loss of outer retinal function associated with photopsia, with minimal or no fundoscopic changes...
Incidence and risk factors of ocular hypertension following PPV and SOI
In this prospective, interventional study the authors evaluated the risk factors for elevated intraocular pressure (IOP) after pars plana vitrectomy (PPV) with silicone oil injection (SOI). This study included 254 eyes of 254 patients, with a mean age of 55.33...
Correlation between anti-retinal antibodies and proliferative vitreoretinopathy (PVR)
The pathological basis of PVR is not clearly understood and there are no effective medications targeting this condition. This cross-sectional study looked at the possible association of anti-retinal antibodies with patients with PVR and retinal detachment (RD). Aqueous and vitreous...
Automated grading of diabetic retinopathy: is it possible?
Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes and a leading cause of blindness worldwide. However, much of this diabetic blindness can be delayed or even prevented with timely diagnosis and proper treatment. For this reason, regular screening...
The effect of everolimus on retinal pigment epithelium and proliferative vitreo-retinopathy
The principal cells involved in proliferative vitreo-retinopathy (PVR) are retinal pigment epithelial cells (RPE). Everolimus is a drug used in renal cell carcinoma which targets and inhibits a key regulatory protein in cancer (mTOR). In this study, the authors investigated...
ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy
Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...
Somatostatin protects retinal pericytes
Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...
ROP ocular outcomes after Bevacizumab treatment
The relationship between refractive outcomes and biometric parameters were evaluated following intravitreal Bevacizumab (IVB) monotherapy. Sixty-three infants were grouped into 1) infants treated with VB monotherapy for ROP (six with zone 1 and eight with posterior zone II retinopathy of...
A possible biomarker for diabetic retinopathy
Diabetic retinopathy (DR) is the most common form of diabetic eye disease, characterised by exudates, microaneurysms and haemorrhage. Early diagnosis is crucial for preventing visual loss. The risk of developing diabetic retinopathy is known to increase with age as well...
