Radiation maculopathy
1 December 2018
| Jonathan Chan
|
Retina / Uvea / Vitreous
|
Inflammation, Macula, Pathology, Retina, Treatment Medical
This is a retrospective non-randomised study of 13 consecutive eyes of 13 patients affected by radiation maculopathy secondary to eye irradiation for primary uveal melanoma (Iodine-125 brachytherapy). All patients were treated with a single intravitreal 0.7mg dexamethasone implant and full...
Reduction of severe visual loss and complications following IAC for RB
1 October 2018
| Jonathan Chan
|
Retina / Uvea / Vitreous
|
Child health (paediatrics), Electrophysiology, Neoplasia, Retina, Vision
This was a retrospective cohort study of patients with retinoblastoma (RB) who required intra-arterial chemotherapy (IAC) between 2013 and 2015, who had relapsed following systemic chemotherapy. A total of nine patients were included in the study and their ocular complications...
International variations in ROP treatment
1 August 2018
| Jonathan Chan
|
Retina / Uvea / Vitreous
|
Child health (paediatrics), Epidemiology, Retina
A retrospective cohort review of 48,087 premature infants weighing <1500 gm between 24 to 27 weeks gestation, from 11 high income countries in Australia, New Zealand, Canada, Finland, Israel, Japan, Spain, Sweden, Switzerland, Tuscany (Italy) and the UK . By...
CD40L activation of human RPE cells
1 August 2018
| Graham Wallace
|
Retina / Uvea / Vitreous
|
AMD, Age-related macular degeneration, CD40L, IL-1β, Inflammasome, MCP-1, RPE, Retinal pigment epithelium
Age-related macular degeneration (AMD) is the leading cause of reduced visual acuity in the elderly worldwide. The risk factors involved in AMD include smoking and diet, while genetics have been shown to have a significant role. Recently a link between...
Treatment of Type 1 ROP with intravitreal bevacizumab or laser photocoagulation according to retinal zone
1 April 2018
| Jonathan Chan
|
Paediatric Ophthalmology / Strabismus
|
Child health (paediatrics), Neovascularisation, Optics and Refraction, Retina
This is a retrospective review of charts of 54 consecutive very low birth weight (VLBW) infants between June 2011 and January 2015 from Berlin, Germany. Type 1 ROP (posterior ROP, n=33; peripheral zone 2, n= 21) were treated with either...
IAC vs. IVC chemotherapy for RB
1 April 2018
| Jonathan Chan
|
Paediatric Ophthalmology / Strabismus
|
Child health (paediatrics), Neoplasia, Retina, Treatment Medical
This a single centre retrospective review of consecutive patients between 1997 and 2014, of all sporadic unilateral retinoblastoma (RB) group D cases, treated with combined intravenous chemotherapy (IVC) and focal treatments (1997- 2008), or intra-arterial chemotherapy (IAC) treatment (2008 to...
Conversion factors for fovea on / off detachments
This is a retrospective study of medical records in a single unit over a 14 year period from January 2001 – December 2014, of patients who converted from fovea-on to fovea-off rhegmatogenous retinal detachment (RRD). Ten cases were identified while...
Importing iron to the retina
1 October 2017
| Graham Wallace
|
Retina / Uvea / Vitreous
|
Age-related macular degeneration (AMD), Ceruloplasmi, Hepcidin, Hephaestin, Iron, Retina, Zip14, Zip8
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...
Retinitis pigmentosa (RP) associated cystoid macular oedema (CMO)
This is a review article from two units in the UK and Australia, highlighting the supporting evidence of possible pathogenesis and treatment modalities of CMO in RP. The authors proposed that the likely mechanisms for RP-CMO involved the breakdown of...
Incidence and factors associated with complication of sutured and sutureless cataract surgery following PPV
This is a retrospective review of 485 patients who had undergone phacoemulsification and IOL implantation after previous pars planar victrectomy (PPV) surgery between May 2000 and May 2014. The incidence and factors contributing to complications were studied. The most common...
Vitrectomy after ocriplasmin for VVMT adhesion of MH study
This is a multicentre retrospective study of 51 eyes that received intravitreal ocriplasmin between January 2013 to January 2014 for symptomatic vitreomacular (VMT) +/- macular hole (MH), and then went on to PPV for persistent pathology, comparing a control group...
Intravitreal bevacizumab vs. ranibizumab in the treatment of macular oedema due to BRVO
This is a randomised, prospective, non-inferiority trial of 75 patients with macular oedema due to a branch retinal vein occlusion (BRVO) who received intravitreal injections of ranibizumab or bevacizumab after 1:1 block randomisation. This study is to measure the difference...
