Intravitreal bevacizumab vs. triamcinolone in patients with DMO at the time of cataract surgery
1 October 2016
| Anjali Gupta
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Retina / Uvea / Vitreous
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bevacizumab, cataract surgery, diabetic macular oedema, randomized clinical trial, triamcinolone
This prospective, single masked randomised control trial (RCT) compared visual and anatomical outcomes when either intravitreal bevacizumab (BVB) or triamcinolone (TA) was administered at the time of cataract surgery and at subsequent review, if required, in patients with diabetic macula...
Case report of Leber hereditary optic neuropathy (LHON)
1 October 2016
| Claire Howard
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Neuro-Ophthalmology
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Central scotoma, Leberhereditary optic neuropathy, macular hole
This case report presents a 74-year-old male patient who developed LHON, with a previous diagnosis of bilateral macular holes. LHON occurs predominantly in healthy young men and onset in older age ranges increases the likelihood that the patient will have...
Differential diagnosis in cases of suspected neuroretinitis
1 June 2016
| Claire Howard
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Neuro-Ophthalmology
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Cat scratch disease, macular star, neuroretinitis, optic disc oedema, rickettsiosis, systemic hypertension
Neuroretinitis is a form of optic neuropathy typically characterised by acute unilateral visual loss with optic disc oedema and macular exudates arranged in a star figure around the fovea (complete or partial star). The purpose of this study was to...
Intravitreal triamcinolone for uveitic macular oedema
1 June 2016
| Saruban Pasu
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Retina / Uvea / Vitreous
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Intravitreal injection, macular edema, steroid, triamcinolone, uveitis
This paper from South Korea reports on a prospective, double blind, randomised clinical study designed to evaluate the additional benefit of intravitreal triamcinolone (TA) administration for noninfectious uveitic macular oedema as an adjunct therapy to systemic anti-inflammatory treatment. Patients were...
The rarebit vision test for macular conditions
1 October 2015
| Nana Theodorou
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Retina / Uvea / Vitreous
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age-related macular degeneration, macula, macular oedema, rarebit, vision test, visual acuity
Rarebit testing is used to measure low degrees of neuro-visual damage and is available for free on the internet. It consists of a fixed bright light dot presented on a black background. During testing it is presented briefly at different...
Lucentis for pseudophakic CMO
1 October 2015
| Saruban Pasu
|
Retina / Uvea / Vitreous
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Cataract, Irvine-Gass syndrome, cystoid macular edema, phacoemulsification, ranibizumab
Pseudophakic cystoid macular oedema (CMO) develops angiographically in up to 20-30% after uneventful phacoemulsification. This study aimed to evaluate the potential efficacy and safety of intravitreal ranibizumab in patients with pseudophakic CMO after cataract surgery. Seven eyes were included in...
Transfected RPE cells inhibit AMD in rats
1 August 2015
| Graham Wallace
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Choroidal neovascularization, Fibulin-5, Retinal pigment epithelium, Transplantation
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...
Is an increased homocysteine level associated with greater risk of AMD?
1 June 2015
| Jonathan CP Roos
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Women's Health Study, homocysteine, prospective cohort, risk factor
Basic research studies have implicated homocysteine in causing vascular endothelial dysfunction and inflammation, and this has been borne out in large observational studies which suggested that elevated homocysteine is associated with increased risk of cardiovascular disease. In order to determine...
RaScaL Study
1 June 2015
| Sofia Rokerya
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Retina / Uvea / Vitreous
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Diabetic macular edema, Fluorescein angiography, Anti-VEGF, Ranibizumab, Laser photocoagulation, Combination therapy, Optical coherence tomography
The RaScaL study was a six month, single-centre, controlled, prospective phase I/II study in which subjects with diabetic macular oedema (DME) and associated peripheral nonperfusion on ultrawide-field fluorescein angiography (UWFA) were randomised to: (1) study arm: ranibizumab (0.5 mg) injection...
Intravitreal injection related endophthalmitis
1 April 2015
| Jaya Myneni
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Retina / Uvea / Vitreous
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Age-related macular degeneration (AMD), endophthalmitis, intravitreal injection, post-injection complications, vascular endothelial growth factor (VEGF)
This article reviews the incidence, clinical findings, risk factors, management and visual outcomes in intravitreal injection related endophthalmitis. Incidence of this complication is reported to be in the range of 0.038% to 0.065% (1 in 2000-3000 injections). Patients present typically...
Choroidal and macular thickness in nonarteritic anterior ischaemic optic neuropathy
1 December 2014
| Claire Howard
|
Neuro-Ophthalmology
|
Choroidal thickness, enhanced depth imaging, macular thickness, nonarteritic anterior ischemic optic neuropathy, optical coherence tomography
This study evaluates the choroidal and macular thickness in patients with chronic nonarteritic anterior ischaemic optic neuropathy (NA-AION). Two groups of subjects were compared, group one included 20 eyes with chronic NA-AION and group two, 31 healthy control eyes. The...
Comparison of ganglion cell thinning in glaucoma vs. macular hole repair
1 December 2014
| Khadijah Basheer
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Retina / Uvea / Vitreous
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Ganglion cell complex, PhNR, glaucoma, macular hole, photopic negative response
This prospective study compared the changes in the photopic negative response of the focal macular electroretinogram (fmERG) caused by retinal ganglion cell complex (GCC) thinning at the macula between patients with open angle glaucoma (OAG) and 12 months after successful...
