Air toxicity on retinal pigment epithelium
1 August 2015
| Khadijah Basheer
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Retina / Uvea / Vitreous
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Air toxicity, internal gas tamponade, pars plana vitrectomy, pneumoretinopexy, retinal pigment epithelium
This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...
Structural effects of migraine on the retina
1 June 2015
| Claire Howard
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EYE - Neuro-ophthalmology
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Migraine, retinal nerve fibre layer thickness, spectral-domain optical coherence tomography
Migraine is a common, chronic, multifactorial neuro-vascular disorder typically characterised by recurrent attacks of disabling headache and autonomic nervous system dysfunction (migraine without aura). Up to one third of patients also have neurological aura symptoms (migraine with aura). The objective...
Nicotine accelerates diabetes induced retinal changes
1 June 2015
| Khadijah Basheer
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Retina / Uvea / Vitreous
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Diabetes, SD-OCT, SLO, neurons, nicotine, retinal thickness
This study investigated the influence of nicotine in an experimentally induced diabetic rat model. They used non-invasive high-resolution spectral domain optical coherence tomography (SD-OCT) imaging to provide quantitative information on the temporal alterations of retinal structures at the micrometer resolution...
Are retinal vein occlusions seasonal? And if so why might that be?
1 June 2015
| Jonathan CP Roos
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Retina / Uvea / Vitreous
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Central retinal vein occlusion, Sweden, incidence, seasonality, vitamin D
Some studies have reported a strong seasonal pattern to central retinal vein occlusion (CRVO) occurrence with a peak in January, but other studies have failed to replicate this finding. The authors sought to determine data for Stockholm’s seasonal variation in...
Diagnostic procedures in vitreoretinal lymphoma.
1 December 2014
| Nikolaos D Georgakarakos
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Retina / Uvea / Vitreous
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Biopsy, diagnosis, masquerade, vitrectomy, vitreoretinal lymphoma
This paper presented a retrospective review of medical records of HIV negative immunocompetent patients diagnosed with vitreoretinal lymphoma between 1994 and 2012. The aim of the paper was to evaluate the type and number of diagnostic interventions required to confirm...
Akimba mice, a model of human diabetic retinopathy
1 October 2014
| Graham Wallace
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Retina / Uvea / Vitreous
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Akimba, BRB, PLVAP, blood-retinal barrier, diabetic macular edema, diabetic retinopathy, mouse models, retina
Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...
Early surgery for epiretinal membrane
1 October 2014
| Nana Theodorou
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Retina / Uvea / Vitreous
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epiretinal membrane, combined phakovitrectomy, OCT
This was a retrospective case review study in 120 consecutive patients with idiopathic epiretinal membrane. The average patient age was 72 years with a mean follow-up of 6.5 months. Inclusion criteria consisted of symptomatic patients with visual acuity of 1.0...
Spectral domain OCT vs. confocal scanning laser ophthalmoscope in measuring RNFL thickness
1 June 2014
| Anjali Gupta
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Ophthalmology
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Cirrus optical coherence tomography, Heidelberg retinal tomograph 3, retinal nerve fibre layer thickness
The aim of this prospective study was to compare the retinal nerve fibre layer thickness (RNFL) measurements obtained from the Cirrus optical coherence tomography (spectral domain OCT) with the Heidelberg Retinal Tomograph 3 (HRT3, confocal scanning laser ophthalmoscope). Eighty-eight normal...
New mouse model of diabetes mellitus
1 April 2014
| Graham Wallace
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Retina / Uvea / Vitreous
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aldose reductase, cell signaling P-ERK1/2, P-SAPK/JNK, P-Akt, diabetic rats, diabetic retinopathy, green fluorescent proteins, growth factors VEGF, bFGF, TGF-β, retinal vascular changes, transgenic diabetic mouse models
Diabetic retinopathy (DR) is a serious complication of diabetes. It is driven by the loss of pericytes, cells which control vascular function, due to excess formation of sugar alcohols by the enzyme aldose reductase (AR). AR has been shown to...
Ocular characteristics in Marfan syndrome
1 February 2014
| Nana Theodorou
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EYE - Cataract, EYE - Refractive
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Marfan syndrome, aphakia, axial length, cataract, ectopia lentis, flattened cornea, myopia, pseudophakia, retinal detachment
Marfan syndrome (MFS) is a genetic disorder with clinical manifestations associated with cardiovascular, ocular and skeletal organ systems. Typical signs are descending aortic root aneurysms, ectopia lentis, tall stature and scoliosis. This observational study looked at the ocular characteristics, visual...
Density of cataract and its influence on retinal nerve fibre layer thickness
1 December 2013
| Nana Theodorou
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Retina / Uvea / Vitreous
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cataract, image quality, optical coherence tomography, retinal nerve fibre layer
The aim of this study was to further define and model the influence of cataract on spectral domain optical coherence tomography (SDOCT) image quality and retinal nerve fibre layer (RNFL) thickness measurements. OCT quality is influenced by opacities in the...
