Use of Leflunomide as a treatment for paediatric chronic uveitis
Leflunomide is a disease modifying anti-rheumatic drug approved for treatment of rheumatoid arthritis and psoriatic arthritis in adult patients. This study reports five illustrative case reports of children using Leflunomide as an adjunct treatment with anti-tumour necrosis factor (TNF) agents...
Treatment of progressive keratoconus
This study aimed to analyse the clinical results of accelerated iontophoresis-assisted epithelium corneal cross-linking (i-ON CXL) to evaluate the risk factors for keratoconus progression after treatment, and the safety and efficacy of re-treatment using epithelium-off CXL protocol in paediatric patients....
Characteristics of cherry red spot on optical coherence tomography
In this study the authors report optical coherence tomography (OCT) characteristics of cherry red spot from three cases of Tay-Sachs and one case of Niemann Pick diseases to determine associated factors and potential visual implications. This was a retrospective case...
Rate and predisposing factors for post-vitrectomy cataract formation in children
This study was a retrospective analysis of post-vitrectomy cataract formation in the general paediatric population. The authors aimed to determine the number of phakic children needing cataract surgery after vitrectomy surgery and related perioperative factors. The study was a 10-year...
Normative reference values for optic nerve sheath diameter in children
The purpose of this study was to measure optic nerve sheath diameter (ONSD) in paediatric patients without pathology using brain CT performed for various reasons and to provide normal tomographic reference values. This was a retrospective study of CT scans...
Infantile nystagmus syndrome and use of genetic testing
This review aimed to assess the clinical utility of genetic testing for individuals with infantile nystagmus syndrome. The authors define infantile nystagmus syndrome as having an onset before six months of age, binocular and conjugate. The literature search was conducted...
Low-dose atropine 0.01% for the treatment of childhood myopia: a pan-India multicentric retrospective study
This is a retrospective multicentre study (20 centres) in India over two years, monitoring the progression of myopia after starting treatment with 0.01% atropine drops. Seven-hundred and thirty-two children were recruited in the study, between six and 14 years old,...
Autofluorescence patterns in subretinal haemorrhages associated with neovascular age-related macular degeneration
The aim of this retrospective study was to describe the surgical results and fundus autofluorescence (FAF) patterns occurring in sub-macular haemorrhage (SMH) of duration <60 days in age-related macular degeneration (AMD). Notes from 39 eyes of 39 patients with SMH,...
Spot diagnosis? The white dot syndromes
This review article provides an up-to-date summary of white spot syndromes. The authors explain that the white spot syndromes form a group of inflammatory retinal disorders with distinct lesion distribution and progression patterns. Multimodal imaging has revealed unique phenotypes, enhancing...
The use of adalimumab for relapse in patients with Vogt-Koyanagi-Harada disease
In this retrospective, multi-centre, cohort study, the efficacy and safety of Adalimumab (ADA) treatment for the exacerbation or recurrence of Vogt-Koyanagi-Harada (VKH) patients was assessed by investigating the medical records of patients who had received ADA treatment for more than...
Updated staging of LCHADD retinopathy
The authors present their proposal for an updated staging system for Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase (LCHAD) deficiency retinopathy. This is a rare mitochondrial disease due to deficiency of the long chain fatty acid oxidation pathway. Forty patients who were part of...
Outcomes following repair of early-onset versus delayed-onset rhegmatogenous retinal detachments (RD) after acute posterior vitreous detachment (PVD)
This is a retrospective single centre comparative interventional study of 210 patients in total, between 2015 to 2020, presenting with delayed RD (diagnosed >42 days after initial acute PVD presentation) compared with a 2:1 age and gender-matched acute RD cohort...