Corneal dellen following strabismus surgery
3 October 2022
| Fiona Rowe (Prof)
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Paediatric Ophthalmology / Strabismus
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Cornea, dellen, strabismus surgery
This study aimed to evaluate the frequency of corneal dellen (CD) development, the healing process and associated factors that affect the development and healing of CD formation after strabismus surgery. This study retrospectively reviewed 1264 eyes of 714 patients from...
Differences in elastometry of cornea and optic nerve head in both eyes of patients with NAION
1 February 2019
| Claire Howard
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Neuro-Ophthalmology
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Corneal hysteresis, corneal resistance factor, non-arteritic anterior ischaemic neuropathy, optic nerve head biomechanics, real-time elastography
Non-arteritic anterior ischaemic optic neuropathy (NAION) is an important cause of visual loss in the middle aged and elderly population. This prospective cross-sectional study investigates the biomechanical properties of optic nerve head (ONH) and cornea in both eyes of patients...
MicroRNA inhibits corneal neovascularisation
1 August 2018
| Graham Wallace
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EYE - Cornea, EYE - General
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Biomechanical stress, Corneal epithelium, MicroRNA-204, Neovascularization, VEGF, VEGFR2
MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...
Corneal stroma modelling under hypoxic conditions
1 August 2018
| Graham Wallace
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EYE - Cornea, EYE - General
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Confocal fluorescence microscopy, Cornea, Corneal organ culture, Extracellular matrix, Stroma
The cornea is exposed to hypoxia under several conditions including sleep, inflammation and wound healing. Being an avascular tissue to maintain transparency, how the cornea homeostatic controls oxygen tension is important. To address this process two models were utilised; a...
Transcriptomic analysis of ocular tissues
1 August 2018
| Graham Wallace
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Glaucoma
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Ciliary body, Cornea, Gene expression, Glaucoma, RNA sequencing, Trabecular meshwork, Transcriptome
Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...
Treatment of severe chronic ocular graft-versus-host disease
1 February 2018
| Jonathan Chan
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EYE - Cornea, EYE - General
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Cornea, Inflammation, Treatment Medical, Wound healing
A retrospective study from Cologne, Germany, between November 2012 to March 2015, of 17 patients with graft-versus-host disease (GVHD) treated with 100% single use vials autologous serum eye drops in sealed system. Visual acuity, corneal staining, frequency of artificial tears,...
Impact on the corneal and anterior chamber characteristics after femtosecond laser cataract surgery
1 December 2017
| Mrinal Rana
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Oculoplastics, Orbit
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Corneal topography, femtosecond laser, femtosecond laser-assisted cataract surgery, laser flare photometry, phacoemulsification
Femtosecond laser cataract surgery (FLACS) is being increasingly used in the preparation for cataract surgery. Benefits of circular capsulorrhexis and reduced phacoemulsification energy have been shown in the literature. This study was designed to assess the anterior chamber characteristics and...
Clinical outcomes of AMT in acute ocular chemical injury
1 August 2017
| Jonathan Chan
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EYE - Cornea, EYE - General
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Cornea, Inflammation, Ocular surface, Stem Cells, Treatment Surgery
This is a retrospective study of patients from two units in Germany and UK between 1998 and 2008. The ocular chemical burns were classified by Roper-Hall and Dua classifications. A total of 72 eyes of 54 patients aged 37.3 years...
Stromal cell alignment in damaged cornea
1 August 2017
| Graham Wallace
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EYE - Cornea, EYE - General
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Confocal microscopy, Corneal wound healing, Extracellular matrix, SHG imaging
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...
C-spp corneal consequences
This is a retrospective review of microbiological records of 22 patients, who had presented at the LV Prasad Eye Institute, India, between June 2009 and December 2012. The corneal scrapings were performed in all patients and had yielded significant growth...
Limbal melanocytes and the stem cell niche
1 February 2016
| Graham Wallace
|
Retina / Uvea / Vitreous
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Cell interactions, Cornea, Limbal stem cells, Melanocytes, Stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...
Secondary iris-claw anterior chamber lens implantation in patients with aphakia without capsular support
1 August 2014
| Jonathan Chan
|
EYE - Cataract, EYE - Refractive
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Anterior chamber, Cornea, Lens and zonules, Optics and Refraction, Treatment Surgery
This retrospective, non-randomised, non-comparative, interventional study including 128 eyes of 124 patients that presented with aphakia with no capsular support. All patients consecutively underwent Artisan iris-claw intraocular lense (IOL) implantation between 1997 and 2010. The inclusion criteria were: aphakic without...
