Leber’s hereditary optic neuropathy: from lab to clinic
1 October 2016
| Chrysostomos D Dimitriou
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Neuro-Ophthalmology
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Hereditary optic neuropathy, Leber hereditary optic neuropathy, mitochondrial optic neuropathy, optic neuropathy
Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...
Retinal changes in Leber hereditary optic neuropathy
1 August 2016
| Claire Howard
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Neuro-Ophthalmology
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Ganglion cell complex, Leber hereditary optic neuropathy, optical coherence tomography, retinal nerve fibre layer
The objective of this study was to describe the changes in the retinal ganglion cell complex (GCC) relative to the retinal nerve fibre layer (RNFL) over time, in patients with Leber’s hereditary optic neuropathy (LHON). For this study, 21 patients...
