This Japanese study compared the choriocapillaris (CC) nonperfusion area as measured on OCTA with areas of macular atrophy (MA) measured by fundus autofluoresence (FAF). A total of 44 eyes were assessed (31 were treated with anti-VEGF alone and 13 had combined (photodynamic therapy – (PDT)). Most CC nonperfusion areas measured on OCTA were larger than the MA area measured on FAF. The area of CC nonperfusion in all cases included more than 50% of the MA area. The MA area was completely encompassed by the CC nonperfusion area in 11 eyes (25.0%). The CC nonperfusion area was larger than the MA area in 39 eyes (88.6%), and there was a linear relationship between the two variables. Choriocapillaris nonperfusion areas were significantly larger in eyes treated with combined PDT than in eyes treated with anti-VEGF therapy alone (P<0.05). Macular atrophy areas were significantly larger in eyes treated with combined PDT than in eyes treated with anti-VEGF therapy alone (P<0.05). No significant correlation was observed between the total number of anti-VEGF injections and CC nonperfusion area. These results suggest that CC nonperfusion occurs simultaneously, or earlier than MA development.
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