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Rituximab as an immunosuppression treatment for thyroid eye disease

Thyroid eye disease is traditionally treated with high dose glucocorticosteroids and surgical orbital decompression, where responses are often inadequate. This medical treatment is centred around symptom control and reduction of thyroid hormone synthesis, not immunosuppression. Rituximab is an anti-CD20 monoclonal...

Froben for anterior scleritis

Flurbiprofen (Froben) is one of the nonselective cyclooxygenase (COX) inhibitors blocking both COX-1 and COX-2 pathways. Agrawal et al. undertook a retrospective cohort study to determine the effectiveness of oral Froben in managing noninfectious, non-necrotising anterior scleritis. One hundred and...

Ocular complications in retinal vasculitis

In this retrospective study the authors aimed to characterise the incidence rates of visual loss and ocular complications associated with retinal vasculitis (RV – annual incidence of 1-2/ 100000/ per annum). A secondary objective was to compare the visual outcomes...

Analysis of risk factors for intraocular pressure rise following insertion of fluocinolone acetonide injection in uveitic patients

For this study, the authors analysed the pooled data from three phase2b / 3 multi-centre randomised controlled trials carried out over three years. Included patients had undergone at least one of the following treatments: 1) systemic therapy (corticosteroid / immunosuppressant...

What effects do repeated Ozurdex implants have in paediatric uveitis?

The aim of this retrospective study was to assess the anatomical and functional results, as well as complications of repeated Ozurdex intravitreal implants in a paediatric (non-infectious) uveitis cohort. Twenty-two eyes (16 patients) received 35 Ozurdex implants over a six...

Keratolimbal allograft and tumour transmission

This case report describes tumour transmission from keratolimbal allograft donor to recipient. A 68-year-old woman underwent keratolimbal allograft (KLAL) for limbal stem cell failure from a donor, who died of invasive breast carcinoma that had metastasised to multiple levels of...

Uveitis and juvenile arthritis costs

The purpose of this study was to evaluate whether cost, prior insurance authorisation concerns and subspecialty practice influence therapeutic decisions in the treatment of uveitis associated with JIA. The authors developed an email questionnaire that included a brief vignette of...

All you need to know about PIC

This is a review article of punctate inner chorioretinopathy (PIC). The authors detail the epidemiology and clinic presentation of the disease. They recognise the challenge of an accurate diagnosis due to its resemblance to other posterior uveitic entities. Multimodal imaging...