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MicroRNAs in cataract
In an ageing population cataract formation is one of the leading causes of blindness. Cataracts are caused by a failure to clear accumulating aggregated proteins in the lens. MicroRNAs are small non-coding transcripts which bind to specific mRNAs acting at...
Maintenance therapy for CMV endotheliitis
Cytomegalovirus (CMV) has been associated with corneal endotheliitis, leading to endothelial cell loss and corneal decompensation. CMV corneal endotheliitis recurrence can affect between 5-60% of eyes after cessation of anti-CMV therapy. Each recurrence of endotheliitis has a detrimental effect on...
A case report of visual loss as a consequence of coeliac disease
The authors present a case of permanent visual loss secondary to occipital lobe calcification in coeliac disease, the first reported such case. The 58-year-old man had been diagnosed with coeliac disease 20 years prior to his visual investigations and had...
Cyclosporine A and pterygium fibroblasts
The matrix metalloproteinases (MMP) are a family of structurally related zinc-dependent extracellular matrix degrading proteinases that have been implicated in facilitating the migration and growth of pterygia. Both MMP- 3 and MMP-13 were found to be overexpressed in the fibroblasts...
A case series of acute visual loss following excessive alcohol and / or drug use
This study presents three cases of so called Saturday night retinopathy, an acute visual loss following intravenous drug abuse and stupor, leading to continuous pressure on the orbit while asleep. All three cases presented with acute vision loss and had...
Rare case reports of benign optic glioma in adults with clinically aggressive nature
Primary optic nerve gliomas are most commonly benign and occurring in childhood. Malignant optic gliomas occur in adulthood and follow an aggressive course usually leading to blindness and death within months. This paper describes the clinical and histopathological features of...
Diagnostic procedures in vitreoretinal lymphoma.
This paper presented a retrospective review of medical records of HIV negative immunocompetent patients diagnosed with vitreoretinal lymphoma between 1994 and 2012. The aim of the paper was to evaluate the type and number of diagnostic interventions required to confirm...
MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
Autophagy in lens mitochondria loss
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...
A case report of cavernous sinus syndrome following dental procedure
This case report describes a patient presenting with painful diplopia as a consequence of root canal dental treatment. Following root canal treatment a non-resolving tooth pain led to a decision to extract the tooth, leading to onset of severe periorbital...
Surgery for lost inferior rectus muscle
This prospective study evaluated the impact of simultaneous ipsilateral superior rectus (SR) recession and superior rectus (IO) anterior transposition on the primary position alignment in six patients with traumatic loss of the inferior rectus (IR) muscle. Five males and one...
