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Atrophy and anti-VEGF

The aim of this study was to investigate treatment factors, along with ocular and systemic factors for their association with macular atrophy (MA) incidence in eyes with neovascular age-related macular degeneration (nAMD) treated with anti-VEGF aflibercept or ranibizumab according to...

Management and outcomes of congenital fibrovascular pupillary membranes (CFPM)

Congenital fibrovascular pupillary membranes (CFPM) is defined as a white fibrous membrane across the pupil which may be an ectopic iris tissue arising from the aberrant migration of neural crest cells or a variant of persistent fetal vasculature. The authors...

Outcomes after surgical excision of limbal dermoid

The authors aimed to report the visual and refractive outcomes and complications of simple excision of limbal dermoid (LD) sparing the visual axis and Descemet’s membrane in children aged ≤8 years. This was a retrospective review over 2000-2019 including 19...

Ocular Surface Disorders

This publication provides an excellent overview of ocular surface disease (OSD). Dry eye disease (DED) is the commonest OSD. There has been a recent explosion, both in terms of its diagnosis and the treatments that are available. A textbook that...

Adjuvant oral voriconazole or oral ketoconazole for fungal keratitis

This randomised double-blinded trial examined clinical outcomes of 50 patients with severe fungal keratitis treated with either adjuvant oral voriconazole or oral ketoconazole. Inclusion criteria were culture or smear proven fungal ulcers >5mm in maximum diameter, involving >4mm of the...

Boston type I keratoprosthesis for limbal stem cell deficiency

Boston type I keratoprosthesis (KPro) long-term outcomes were compared in patients with and without limbal stem cell deficiency (LSCD) in this retrospective study. In the 11 year period 68 procedures were performed in individuals with LSCD, and 105 procedures in...

Tear film thickness after treatment with artificial tears in patients with moderate dry eye disease

In recent years artificial tear drops addressing tear film osmolarity have come onto the market. Increased tear evaporation and reduced tear volume results in tear hyperosmolarity. This triggers an inflammatory process leading to apoptosis of goblet and epithelial cells. Trehalose,...

Ovarian hormones drive onset of Sjogren’s disease in mice

Sjogren’s syndrome (SS) is a debilitating, sight-threatening, systemic autoimmune disease with no effective treatment available. SS is characterised by lacrimal gland lymphocytic infiltration and epithelial cell death, as well as by the presence of serum autoantibodies. Patients have severe dry...

Ocular lubrication versus bandage contact lens in recurrent erosion syndrome (RES)

Twenty-nine patients (eight traumatic, five epithelial basement membrane dystrophy, two idiopathic) were randomised using SPSS to either ocular lubricants or bandage contact lenses (BCLs). Only patients previously treated with ocular lubricants were included. Patients with previous surgery, laser treatment, dry...

Moxifloxacin 0.5% for bacterial keratitis

The authors report on the results of a randomised controlled trial comparing commercially available non-preserved moxifloxacin 0.5% vs. a combination of fortified cefazolin 5% and tobramycin 1.3% in the treatment of moderate bacterial keratitis without perforation. Corneal scrapings were collected...

Mitomycin C versus 5-FU as an adjunctive treatment for trabeculectomy

Antifibrotic agents are used during trabeculectomy (TRAB) to improve long-term surgical success by reducing fibrosis of subconjunctival and episcleral tissue. The purpose of this meta-analysis was to directly compare the efficacy and safety of the two most frequently used antifibrotic...