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Importing iron to the retina
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...
Histopathological changes in rabbit retinitis pigmentosa
The authors report the histopathological changes of retinal ganglion cells (RGCs), optic disc and optic nerve in rabbit with advanced retinitis pigmentosa (RP). RP was recreated in rabbits by using bacterial artificial chromosome transgenesis, with the purpose of increasing understanding...
Syndromic V-pattern management
The authors document their experience in the management of four cases of Crouzon syndrome and review the anatomical extraocular muscle anomalies noted during surgery. Horizontal strabismus surgery varied in each of the four cases according to individual extraocular muscle abnormalities...
Correlation between structural and functional status of optic nerve and retina in multiple sclerosis
Multiple sclerosis (MS) involves autoimmune inflammatory demyelination and axonal degeneration in the central nervous system. Investigation of the retina and optic nerve head (ONH) is an ideal way to visualise this demyelination. This study investigates the functional and structural properties...
Complement Factor H and Factor H-Like protein are expressed in human RPE cells
The role of inflammation in age-related macular degeneration (AMD) is well documented and the association of AMD with the inflammatory marker C-reactive protein (CRP) and members of the complement system underline the role of complements in AMD. Human complement factor...
Microperimetry of subretinal drusenoid deposits
Subretinal drusenoid deposits (SDD), originally termed ‘reticular pseudo-drusen’, have recently been identified by histology and optical coherence tomography (OCT) as aggregations located in the subretinal rather than the sub retinal pigment epithelium (RPE) space. These deposits affect the amount of...
HtrA1 enhances cell senescence
A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...On reflection
Welcome one and all to our festive Eye News Dec/Jan 2024. The arrow of time has flown through 2023, landing us at the year’s end, but not before Santa brings you this special delivery. Aside from the partying and generally...Blindness from some inherited eye diseases may be caused by gut bacteria
Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice co-led by a UCL and Moorfields researcher.
Management of large hypertropia due to lost inferior rectus
This case report outlines the management strategy for a 37-year-old male who suffered a penetrating left orbital injury with rupture of the inferior rectus muscle, optic nerve avulsion and vertical deviation of about 90PD. On orbit exploration, the inferior rectus...
