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Long-term use of botulinum toxin for hemifacial spasm and blepharospasm

The authors conducted a retrospective review of clinical / procedure documentation for consecutive blepharospasm (BEB) and hemifacial spasm (HFS) patients undergoing treatment with onabotulinum toxin A (Botox) in one clinic setting over the past 20 years. They report on the...

Environmental variations in endophthalmitis

In this retrospective cohort study, the authors looked at seasonal and environmental variations in 171 endophthalmitis cases out of 423,297 intravitreal injections. The incidence of this complication was not correlated to monthly snowfall, rainfall, or average temperature. There was no...

BT for convergence spasm

The aim of this study was to analyse the response of a cohort of patients with convergence spasm to the injection of botulinum toxin (BT) in the medial rectus muscle. This was a retrospective study of six patients with a...

Importing iron to the retina

In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...

BT as a diagnostic tool in Duane’s retraction syndrome

This study evaluated the effects of botulinum-toxin (BT) on management of Duane’s retraction syndrome along with how BT can be used diagnostically to help with patient expectations and decide management. Functional and psychosocial impact of BT effect was evaluated in...

Prophylaxis for clinical macular oedema after phacoemulsification

The authors report on a retrospective cohort study looking at three different prophylaxis methods for macular oedema after cataract surgery: 1) Topical prednisolone acetate (PA) alone; 2) Topical PA in combination with non-steroidal anti-inflammatory drug (NSAID); 3) Intraoperative subconjunctival injection...

Intravitreal aflibercept for diabetic macular oedema

The VISTA and VIVID randomised phase 3 trial were designed to compare the efficacy and safety of intravitreal aflibercept injections versus laser photocoagulation for diabetic macular oedema (DMO). A total of 872 patients with centrally involving DMO were recruited, and...

Ointment related granulomas post-blepharoplasty

This is a retrospective review of eight patients who developed granulomatous masses after lower lid blepharoplasty. All patients had sutureless bilateral trans-conjunctival surgery, and lubricating ointment was instilled into the inferior fornix postoperatively for two days. Painless lower lid masses...

Brn3b neuroprotective effect in rat glaucoma model

An adeno-associated virus-directed overexpression of the Brn3b protein in hypothesised to confer neuroprotective effects in this paper. This is ultimately tested in a well-accepted rat glaucoma model (Morrison’s model: saline injection into episcleral veins of rat eyes with a force...

Choice of diclofenac or corticosteroids for strabismus surgery

This systematic review was undertaken to analyse the available data on various corticosteroids and diclofenac to determine the most effective postoperative anti-inflammatory agent for patients with strabismus. Twenty-five studies were identified from 1997–2021 and a total of eight met the...

Methotrexate and mycophenolate mofetil for non-infectious uveitis

This is the first reported randomised clinical trial comparing methotrexate versus mycophenolate mofetil (MMF) for the treatment of non-infectious intermediate uveitis, posterior uveitis or panuveitis. To be eligible for recruitment, patients had to be on ≥15mg oral prednisone and demonstrated...