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Stromal cell alignment in damaged cornea

1 August 2017 | | Cornea / External Eye Disease | Confocal microscopy, Corneal wound healing, Extracellular matrix, SHG imaging
Stromal keratocytes are responsible for wound healing in the cornea following damage. Keratocytes at the site of injury become activated and differentiate to myofibroblasts which secrete extracellular matrix (ECM) to close the wound, a response mediated by transforming growth factor...

Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

1 October 2016 | | Retina / Uvea / Vitreous | chemotherapy, intra-ocular tumour, retinal pigment epithelium, retinoblastoma, toxicity
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Penetrating keratoplasties in infants

1 August 2016 | | Cornea / External Eye Disease
This retrospective review looked at endothelial cell counts (ECC) following penetrating keratoplasties (PKP) performed in infants within the first year of their life. One hundred eyes of 71 patients had their first PKP during the study period (1998-2013). In 30%...

Transfected RPE cells inhibit AMD in rats

1 August 2015 | | Retina / Uvea / Vitreous | Age-related macular degeneration, Choroidal neovascularization, Fibulin-5, Retinal pigment epithelium, Transplantation
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...

Time is vision in central retinal artery occlusion

4 August 2021 | | Ophthalmology, Retina / Uvea / Vitreous, Emergency Ophthalmology
Central retinal artery occlusion (CRAO) is a rare but devastating vascular episode that can have severe impact on vision. Treatment is very time-limited and needs to be initiated very quickly to salvage any vision. The majority of patients present to...

Insects, swelling and sight loss: a case of orbital inflammatory syndrome

1 June 2022 | | Ophthalmology
Despite being the most common cause of painful orbital mass in adults and the third most common orbital disease, orbital inflammatory syndrome still proves to be a difficult ocular condition to diagnose, treat, and manage. A 41-year-old lady presented to...

Ocular electrophysiology

1 April 2014 | | Oculoplastics, Orbit
A 34-year-old woman, who is a CEO in a multinational firm, has been losing vision over the last 12 months. She has seen her opticians, who initially tried different glasses but could not improve things. Clinical examination is unremarkable. How...

The management of possibly progressive pterygium

1 February 2015 | | Cornea / External Eye Disease
A 43-year-old Sudanese male patient is referred by his GP with a fleshy lesion encroaching the nasal cornea for the last six months. History Make note of: risk factors, i.e. UV exposure and ocular irritation - history of living in...

Game show freak

3 April 2023 | | Ophthalmology
As a child of the 70s and 80s, there were limited television viewing opportunities. For the duration of the 70s there were only three channels, only moving to four with the launch of Channel 4 in 1982. Not only that,...

Students, soccer and slit-lamps in Ethiopia: a VISION 2020 LINK

1 August 2014 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Glaucoma, Genetics, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
Wachemo University campus. The Ethiopian Government is well aware of the brain drain amongst health workers and, to compensate, is training huge numbers of medical students, nurses and health officers in universities like Wachemo, a massive new University near Hosanna...

Development of retinoblastoma services in Zimbabwe

5 June 2020 | | Ophthalmology, Retina / Uvea / Vitreous
Zimbabwe recognised the need for a paediatric ophthalmology service almost 20 years ago. The economic uncertainty in the country made it difficult to secure financial support, so initial funding came through local donors. Equipment – including vision charts, ophthalmoscopes and...

Development of retinoblastoma care in Indonesia and the role of multidisciplinary team meetings

4 August 2021 | | Ophthalmology, Paediatric Ophthalmology / Strabismus, COVID-19, Retina / Uvea / Vitreous
In the second article of a two-part series (See Part 1 here), the authors focus on the diagnosis and management of retinoblastoma in Indonesia. COVID-19 doesn’t get thanked for many things, but on 19 December 2020 as the world grew...