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Visual prognosis in Irish Leber’s hereditary optic neuropathy

Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...

Should intravitreal steroids be used in the initial treatment of post-op endophthalmitis?

Endophthalmitis following cataract surgery is one of the most feared complications, and can have significant impact on the visual outcomes of patients. The role of steroids in the management of endopthalmitis is controversial. The aim of this paper was to...

Low cost drainage device use in paediatric glaucoma

This is a prospective study from a tertiary referral centre from India of 34 eyes (31 patients) under 16 years with uncontrolled refractory glaucoma with medical treatment. A low cost glaucoma drainage device (GDD) – Aurolab aqueous drainage implant (ADDI),...

Leber’s hereditary optic neuropathy outcomes in an Indian population

A large cohort study in an Indian population is presented, with clinical and genetic profile analysis of patients with Leber’s hereditary optic neuropathy (LHON) treated over a five-year period. The study included 157 patients; 143 male, 14 female (10.2:1 ratio)...

HLA-B27 anterior uveitis

HLA-B27 has previously been shown to have an association with uveitis, ankylosing spondylitis, reactive arthritis, ulcerative colitis and psoriasis. The authors of this review provide an update of the epidemiology of HLA-B27 associated ocular disorders. There is great variation amongst...

Rituximab efficacy for juvenile idiopathic arthritis

This is a retrospective study about the long-term efficacy of rituximab in patients with severe juvenile idiopathic arthritis (JIA)-associated uveitis. A total of eight patients (15 eyes) were recruited in this study in a single tertiary referral centre from Italy....

Clinical characteristics and outcomes of open globe injury

This retrospective cohort study examined consecutive open globe injuries at a tertiary referral centre over a three year period. The aim of the study was to detail the clinical characteristics of open globe injuries and to explore their association with...

Facilitators and barriers to conducting research

A survey of clinicians and researchers across the UK was conducted to identify barriers to research and potential solutions. The authors extracted details of studies listed on the UKCRN database that involved paediatric ophthalmology with recruitment of children. An e-survey...

Uveitis in HIV infected persons

Before the advent of highly active antiretroviral therapy (HAART), uveitis, in particular cytomegalovirus (CMV) retinitis, was the most common cause of visual loss in patients with AIDS. HAART has altered the cause of ocular disease in HIV infected individuals by...