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How to diagnose and treat Acanthamoeba keratitis

Corneal ulceration caused by Acanthamoeba is on the rise, and recent publications indicate an outbreak in the UK over the last few years [1]. Since Acanthamoeba keratitis often presents with atypical features, diagnosis from slit-lamp examination alone can often be...

Oral omega-3 fatty acid treatment for dry eye in contact lens wearers

This study evaluates the effect of dietary omega-3 fatty acid supplementation of dry eye symptoms, tear film tests, and conjunctival impression cytology in patients with contact lens wear-associated dry eye. In this randomised double-blind, multi-centred trial, contact lens wearers (n=...

Bilateral eye pain after contact lens wear: an inadvertent case of chemical eye injury

Introduction There are around 4.1 million contact lens wearers in the UK [1]. While the vast majority of them do not experience any complications, over the past years there have been cases of acanthamoeba keratitis and multiple retained contact lenses...

Quiz Apr/May 2023

History A 76-year-old female presented at her local district general hospital with right decreased visual acuity, glare, and foreign body sensation, in addition to longer-term dry eyes. She was otherwise well. Her past medical history included hypertension. On examination: vision...

New solutions in the prevention and treatment of Acanthamoeba keratitis

The global increase in Acanthamoeba keratitis infections has emphasised the inefficiencies of current treatment and preventative methods, here researchers from the West of Scotland detail a promising new series of compounds that may stem the tide. News headlines detailing horror...

10 daily habits damaging your eyesight and changes you can make to remedy against them

Following World Glaucoma Day on 12 March this year, it is vital that the longevity of our vision is always a priority. However, many of our daily habits contribute to the onset of glaucoma and vision loss.

Immunoglobulin G4-related ophthalmic disease – what is it? (Part 2)

Part 2: Clinical presentation and treatment (see part 1 here) Introduction IgG4-related disease (IgG4-RD) is understood to have a vast clinicopathological spectrum; nearly every organ has had reported involvement. Similarly, IgG4-related ophthalmic disease (IgG4-ROD) is known to affect nearly every...

Quiz Dec/Jan 2023

History A 35-year-old female presented to the emergency eye clinic with an acutely red, painful, photophobic left eye. She was a contact lens-wearer but denied swimming, showering, or sleeping in her lenses. She resided on a farm and worked as...

Idiopathic orbital pseudotumor as first sign of systemic inflammatory disease

The authors describe four children in whom idiopathic orbital pseudotumor (IOP) was the initial solitary finding with systemic inflammatory disease developing later. Four children were seen over a five-year period. Mean age was 9.75 years (2-14). Three were white and...

Differential inhibition of EAU by CTLA4 and IL-6

Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...

Herpes zoster ophthalmicus: a clinician’s perspective

Introduction Herpes zoster, commonly known as shingles, is caused by the reactivation of varicella zoster virus (VZV). The term herpes is derived from a Greek work, herpein, which means ‘creeping’ and the word zoster means a belt or a girdle...

Resurfacing the ocular surface

The ocular surface (OS) is an anatomical and functional unit made of the tear film, the conjunctival, limbal and corneal epithelium, the lacrimal, mucous and meibomian glands and the lids and blink reflex. The tear film is composed of a...