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Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells

1 October 2016 | | Retina / Uvea / Vitreous | chemotherapy, intra-ocular tumour, retinal pigment epithelium, retinoblastoma, toxicity
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...

Resurfacing the ocular surface

1 April 2016 | | Cornea / External Eye Disease
The ocular surface (OS) is an anatomical and functional unit made of the tear film, the conjunctival, limbal and corneal epithelium, the lacrimal, mucous and meibomian glands and the lids and blink reflex. The tear film is composed of a...

Genetic profiling for personalised healthcare solutions in AMD – an update

1 August 2015 | | Retina / Uvea / Vitreous
Age-related macular degeneration (AMD) is a multifactorial condition influenced by genetics and lifestyle factors (Table 1). This article outlines several recent advances in AMD genetics, as well as evolving therapeutic concepts and established practical measures for the treatment and /...

Hot debates in medical retina and imaging: Perspectives from the Controversies in Ophthalmology 2020 virtual conference

5 August 2020 | | Ophthalmology, Retina / Uvea / Vitreous, Imaging
Controversies in medical retina and imaging were debated during the Controversies in Ophthalmology 2020 virtual conference held during two mid-day scientific sessions on 27 and 28 March 2020. The author recounts key perspectives and presents viewpoint recommendations from the Vision...

What's trending Dec/Jan 2019

1 December 2018 | Ophthalmology, Orbit, Emergency Ophthalmology, Cataract and Refractive, Retina / Uvea / Vitreous
On the first day of Christmas, my true love gave to me…A #RyderCup globe injury An unfortunate spectator was hit in the eye by a wayward golf ball during the Ryder Cup, and suffered, as she called it, “a fracture...

Stem cell transplantation and pterygium surgery

28 November 2022 | | Ophthalmology
Pterygium is a benign, fibrovascular overgrowth of bulbar conjunctiva extending onto the cornea and has been associated with ultraviolet (UV) light exposure. The prevalence of pterygium worldwide varies between geographical zones but has been reported to range between three and...

Do steroids prevent progression to proliferative diabetic retinopathy (PDR)?

1 February 2017 | | Retina / Uvea / Vitreous
There is continuing debate on the merits of pan-retinal photocoagulation (PRP) for severe pre-proliferative and proliferative DR versus the newer therapies that inhibit vascular endothelial growth factor (VEGF). This has been hotly debated [1] following the publication of findings from...

Can OCT predict Alzheimer’s disease?

5 February 2020 | | Ophthalmology, Optometry, Imaging
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are based on facts and which are ‘fake news’. Headline: Can OCT predict Alzheimer’s disease? In 1986 Hinton et al. demonstrated evidence of optic nerve degeneration...

The results of the last survey Dec20

7 December 2020 | | Ophthalmology, Cataract and Refractive
The responses to the first question in this survey demonstrate the need for it and the significant variation in practice we see in even relatively simple management decisions. Patients are seen regularly with occludable drainage angles and listed for YAG...

Running a high-volume nurse led intravitreal service using the Sp.eye device – the Stanley Eye Unit experience

2 February 2024 | | Retina / Uvea / Vitreous
Introduction The vast majority of ophthalmology units utilise allied healthcare professionals (AHPs) to deliver intravitreal injections (IVIs). The Royal College of Ophthalmologists issued a statement 10 years ago advocating the use of non-medical practitioners performing IVIs [1]. The main benefit...

A unique case of macular burn from ‘toy’ laser

2 February 2024 | | Emergency Ophthalmology, Ophthalmology
The first laser was created in 1960 and its name is an acronym for ‘light amplification by stimulated emission of radiation’. Laser technology has been used for medical, industrial, research and entertainment purposes in a variety of fields following extensive...

A case of ‘60-day glaucoma’

3 April 2023 | | Ophthalmology
Neovascular glaucoma (NVG) has been called ‘90-’ or ‘100-day glaucoma’ in the past due to its typical development three months after the onset of central retinal vein occlusion (CRVO). In reality, NVG can occur anywhere between two weeks and two...