You searched for "drusen"
ABCA1 mediates lipid efflux in the retina
1 June 2018
| Graham Wallace
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Retina / Uvea / Vitreous
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ABCA1, ApoA-I, Cholesterol efflux, HDL, LXR, RPE
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. There are two forms of AMD, dry and wet, the latter so named because of the presence of choroidal neovascularisation. Both forms lead to retinal pigment...
Microperimetry of subretinal drusenoid deposits
1 February 2014
| Bheemanagouda Patil
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Retina / Uvea / Vitreous
Subretinal drusenoid deposits (SDD), originally termed ‘reticular pseudo-drusen’, have recently been identified by histology and optical coherence tomography (OCT) as aggregations located in the subretinal rather than the sub retinal pigment epithelium (RPE) space. These deposits affect the amount of...
Pegcetacoplan: A breakthrough treatment for dry age-related macular degeneration?
Age-related macular degeneration (AMD) is a degenerative condition affecting the macula, the part of the retina responsible for central vision. It is characterised by the presence of drusen and retinal pigment epithelium (RPE) abnormalities in the absence of other macular...Macula re-attachment following intravitreal ranibizumab in rhegmatogenous retinal detachment
Ranibizumab (Lucentis) is a vascular endothelial growth factor inhibitor (anti-VEGF) used for treatment of choroidal neovascular membrane [1]. We report a case where macula off inferior rhegmatogenous retinal detachment was misdiagnosed as wet age-related macular degeneration (AMD) and three intravitreal...
Differential diagnosis of retinoblastoma and pseudo retinoblastoma
5 April 2022
| Fiona Rowe (Prof)
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Paediatric Ophthalmology / Strabismus
The authors reviewed the rate of pseudo retinoblastoma (PRB) among cases referred for suspicion of RB at a tertiary referral centre in Turkey and the distribution of PRB cases according to age. This was a retrospective study of 549 patients...
Optic nerve swelling – your survival guide (part 1)
1 August 2017
| Ali Yagan
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EYE - Neuro-ophthalmology
Assessment of optic nerve appearance and functions is a daily routine in neuro-ophthalmology. Following a recent high profile court case there has been a significant increase in the amount of referral to ophthalmology departments to assess the optic nerve and...
Genetic profiling for personalised healthcare solutions in AMD – an update
1 August 2015
| Rod McNeil
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EYE - Vitreo-Retinal
Age-related macular degeneration (AMD) is a multifactorial condition influenced by genetics and lifestyle factors (Table 1). This article outlines several recent advances in AMD genetics, as well as evolving therapeutic concepts and established practical measures for the treatment and /...
Uveal melanoma
3 August 2023
| Mertcan Sevgi, Timothy Beckman, Paul Cauchi, Julie Connolly, Vikas Chadha
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EYE - Pathology, EYE - Oncology, EYE - Imaging
Uveal melanoma is the most common primary intraocular tumour. However, they are still rare, with an incidence of 2-8 per million [1]. The presence of a choroidal naevus is a risk factor for uveal melanoma [1]. Patients with choroidal lesions...
SCONe Project seeks participants for patient and public involvement group to revolutionise AMD research
The SCONe project, run by optometrists, ophthalmologists, and researchers from the University of Edinburgh, and funded by Sight Scotland, is appealing for participants to take part in a Patient and Public Involvement (PPI) group focused on revolutionising the detection and management of Age-Related Macular Degeneration (AMD).Optos announces new ultra-widefield colour image modality, providing additional retinal visualisation to eyecare professionals
Optos, Plc, the leading retinal imaging company, announces it is expanding the optomap® ultra-widefield (UWF™) retinal imaging modalities available with the California FA device to further assist eyecare professionals in disease management and treatment planning.
Review of non-arteritic anterior ischaemic optic neuropathy
1 October 2016
| Chrysostomos D Dimitriou
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Neuro-Ophthalmology
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Neuroprotection, optic nerve ischemia, optic nerve vasculature, primate models, rodent models
This article reviews the risk factors, clinical presentation and therapies that have been investigated for non-arteritic anterior ischaemic optic neuropathy (NAAION). Additionally, it provides an update from recent rodent and primate models, offering a new insight into the pathophysiology of...
Type 3 macular neovascularisation (MNV) due to age-related macular degeneration
3 October 2024
| Sofia Rokerya
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Retina / Uvea / Vitreous
This paper systematically reviews and summarises the current knowledge on type 3 neovascularisation due to age-related macular degeneration which is defined as neovascularisation originating from the retinal deep capillary plexus that grows towards the outer retina often penetrating the level...
