You searched for "epithelial"
Biopsy of nasolacrimal duct using sheath guided dacryoendoscopy
1 August 2019
| Rina Bhatt
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EYE - Neuro-ophthalmology
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Dacryoendoscopy, biopsy, immunohistochemistry, nasolacrimal duct obstruction, sheath-guided endoscopic probing (SEP)
In this study the author’s biopsied six eyes of five individuals with recurrent nasolacrimal duct obstruction following a prior dacryoendoscopic probing. All procedures were performed under local anaesthetic, the obstruction or lesion was directly visualised with dacryoendoscope and biopsy was...
Diffuse lamellar keratitis
This study group reviewed cytokine- and chemokine-mediated mechanisms of diffuse lamellar keratitis (DLK) after lamellar corneal surgical procedures. DLK can occur early or late (months to decades) after all lamellar corneal surgeries, including laser in situ keratomileusis, small incision lenticule...Corneal dystrophies simplified
1 February 2017
| Bushra Thajudeen
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EYE - Cornea
Based on biomicroscopic and histopathologic features, corneal dystrophies can be broadly classified into epithelial, Bowman’s layer / anterior stromal, stromal, and endothelial dystrophies. Corneal dystrophies are a group of inherited, bilateral, gradually progressing, non- inflammatory conditions caused by accumulation of...
Limbal melanocytes and the stem cell niche
1 February 2016
| Graham Wallace
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Retina / Uvea / Vitreous
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Cell interactions, Cornea, Limbal stem cells, Melanocytes, Stem cell niche
The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...
MicroRNAs in cataract
1 August 2016
| Graham Wallace
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EYE - Cataract, EYE - Refractive
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Age-related cataract, Lens epithelial cells, Lgr4, MicroRNA let-7b, Ultraviolet irradiation
In an ageing population cataract formation is one of the leading causes of blindness. Cataracts are caused by a failure to clear accumulating aggregated proteins in the lens. MicroRNAs are small non-coding transcripts which bind to specific mRNAs acting at...
Autophagy in lens mitochondria loss
1 April 2014
| Graham Wallace
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EYE - Cataract, EYE - Refractive
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ATG5, FYCO1, FYVE and coiled coil domain containing 1, LC3B, OFZ, Pik3c3, TOM20, autophagy, autophagy-related 5, cataract, differentiation, electron microscopy, lens, microtubule-associated protein 1 light chain 3B, mitophagy, organelle free zone, phosphatidylinositol 3-kinase, catalytic subunit type 3, translocase of the outer mitochondrial membranes 20 kDa
The lens consists of a monolayer of epithelial cells that overlies fibre cells that differentiate from epithelial cells at the equator. While developing, fibre cells need mitochondria to provide energy, as they mature they lose these and other organelles to...
Feb/Mar 2019 Quiz
History A 31-year-old female patient presented with history of gradual downward displacement of the globe over the last six months. The superotemporal mass then became palpable (Figure 1). Lateral orbitotomy was performed following CT scans (Figure 2). Figure 1. Figure...Dec/Jan 2017 Quiz
History An 18-month-old boy presented with a slow growing left anterior orbital lump medially. Examination revealed a palpable mass beneath the skin at the inferonasal aspect without any visual impairment. A CT scan (Figure 1) followed by an excisional biopsy...In vivo confocal microscopy, principles and use in keratitis Part 1: Principles
In 1968 Maurice introduced the concept of high powered specular microscopy, it was in that very year that the first scanning confocal microscope was proposed. Marvin Minsky developed the first confocal microscope in 1955 named the ‘double focusing scanning microscope’....Q&A: Mr Goel and Mr Loomba on alcohol delamination and phototherapeutic keratectomy (PTK) for the treatment of recurrent corneal erosion syndrome
14 June 2023
| Aina Pons, Abhinav Loomba, Siddharth Goel
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EYE - Cornea
Recurrent corneal erosion syndrome is a common, recurrent condition caused by abnormal epithelial adhesion to the underlying basal lamina. Spontaneous breakdown of the corneal epithelium can lead to the sudden onset of ocular pain, blurred vision, tearing and photophobia, typically...
Therapy for limbal stem cell deficiency: cell fate after limbal stem cell transplants
1 October 2014
| Aws Al-Hity, Sanjay Mantry, Ken Lai, K Ramaesh
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EYE - Cornea
“The beauty of scientific research lies in that the search for answers often yields yet more questions.” A large body of evidence points to the corneoscleral limbal location as the repository of putative epithelial stem cells [1]. Thoft proposed the...
Air toxicity on retinal pigment epithelium
1 August 2015
| Khadijah Basheer
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Retina / Uvea / Vitreous
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Air toxicity, internal gas tamponade, pars plana vitrectomy, pneumoretinopexy, retinal pigment epithelium
This study investigated the potential toxic effects of air on primary human retinal pigment epithelial (RPE) cells in vitro. Clinically during pars plana vitrectomy air is used as either a temporary tamponade during air-fluid exchange or mixed with gas to...