You searched for "immunosuppression"
Rituximab efficacy for juvenile idiopathic arthritis
1 October 2016
| Jonathan Chan
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Paediatric Ophthalmology / Strabismus
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Child health (paediatrics), Drugs, Immunology, Inflammation
This is a retrospective study about the long-term efficacy of rituximab in patients with severe juvenile idiopathic arthritis (JIA)-associated uveitis. A total of eight patients (15 eyes) were recruited in this study in a single tertiary referral centre from Italy....
Cytomegalovirus retinitis post intravitreal triamcinolone in an immunocompetent patient with juvenile glaucoma
1 December 2014
| Eneh Jones-Odeh, KS Lim, MR Stanford
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AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
Figure 1: Fundus photograph shows active CMV retinitis four weeks after IVTA in the right eye. Figure 2: Fundus photograph of the left eye with no CMV retinitis; atrophic disc as a result of juvenile glaucoma. Case report A 29-year-old...
Herpes zoster ophthalmicus: the essentials
24 July 2020
| Charles O’Donovan
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Ophthalmology, Optometry, Cornea / External Eye Disease, ONLINE EXCLUSIVE ARTICLES
Herpes zoster, also referred to as shingles, is a common infection most typically caused by the reactivation of varicella zoster virus that lies dormant (sometime for decades) in the dorsal root nerve ganglion following primary chickenpox infection [1]. In 10-20%...
New Treatments in Noninfectious Uveitis
As a specialist registrar training in Aberdeen there were two important lessons I learned which have proved to be invaluable over the years for two very different reasons. The first lesson learned was to never underestimate the wind chill factor...Impact of initial management on relapse in Vogt–Koyanagi–Harada syndrome
3 September 2024
| Zina Mobarak
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Retina / Uvea / Vitreous
In this retrospective, multi-centre, observational study, the impact of the initial management of Vogt-Koyanagi-Harada syndrome (VKHS) was assessed by reviewing the records of all patients diagnosed with VKHS between January 2001 and December 2020 in two French tertiary centres, with...
Profile of sympathetic ophthalmia (SO)
7 April 2021
| Fiona Rowe (Prof)
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Paediatric Ophthalmology / Strabismus
The authors undertook this study to examine the clinical profile of patients aged <18 years with SO over the past 20 years. This was a hospital-based retrospective study from 1997 to 2017. SO is a diagnosis of bilateral panuveitis following...
Systemic anti-inflammatory versus fluocinolone acetonide intraocular implant
1 February 2016
| Brian Ang
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Ophthalmology
In the Multicenter Uveitis Steroid Treatment (MUST) trial, 255 patients with intermediate uveitis, posterior uveitis or panuveitis were randomised to either fluocinolone acetonide intraocular implant or systemic corticosteroid therapy which was supplemented with immunosuppression if required. Patients were followed up...
A case report of Horner syndrome with neuromyelitis optica
1 August 2014
| Claire Howard
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Neuro-Ophthalmology
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Horner syndrome, neuromyelitis optica, NMO IgG antibody
This case report details a patient diagnosed with neuromyelitis optica (NMO) with an associated left Horner syndrome. The female patient presented with neck pain and right hemibody decreased pain and temperature sensation. She then went on to develop left ptosis...
Case reports of neuro-ophthalmological complications of CIPD
1 April 2014
| Claire Howard
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Neuro-Ophthalmology
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Chronic inflammatory demyelinating polyradiculoneuropathy, papilloedema, proptosis
The authors present three cases of neuro-ophthalmological complications of chronic inflammatory demyelinating polyradiculoneuropathy (CIPD). CIPD can lead to prominent nerve hypertrophy which can mimic other forms of neuropathy radiologically. In addition, complications can occur which can cause diagnostic difficulties. All...
A career in uveitis
As he retires from clinical practice, the author looks back on his long career in uveitis and how care of these patients has changed dramatically since his days as an undergraduate. My trainees and fellows are often bored by my...Injection of methotrexate into silicone oil-filled eyes for grade C PVR
1 October 2019
| Sofia Rokerya
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Retina / Uvea / Vitreous
Methotrexate (MTX) is an antineoplastic antimetabolite with immunosuppressant properties. Folate antagonism is known to contribute to the antiproliferative effects of MTX, and release of adenosine from cells and inhibition of polyamines may explain its anti-inflammatory effects. These activities contribute to...
Medical treatment of orbital lymphatic malformations
5 August 2020
| James Hsuan
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Paediatric Ophthalmology / Strabismus
This is a literature review of the use of Sirolimus, to treat orbital lymphatic malformations. Sirolimus is an immunosuppressant used in renal transplants, and acts by inhibiting mammalian target of rapamycin (mTOR), which in turn inhibits activation of T and...