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5497 results found

PD-1 and retinal ganglion cell death

Death of retinal ganglion cells (RGC) in conditions like glaucoma leads to permanent visual loss. RGC death can be due to the initial stress such as raised intraocular pressure or secondary to mechanism such as oxidative stress. Programmed cell death-1...

Limbal melanocytes and the stem cell niche

The cornea is continually regenerated to maintain clear vision, due to a population of stem cells located in the limbal region between the cornea and the conjunctiva. These limbal stem cells (LESC) reside in crypts in structures called the Pallisades...

Hemianopia or visuospatial neglect: differences in information processing

It is widely reported that visuospatial neglect and hemianopia may be superimposed, and disentangling the two conditions can be pose difficulties for clinicians. The authors of this paper explored the differences in implicit information processing which is effective in patients...

Somatostatin protects retinal pericytes

Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...

Managing blepharophimosis

The authors present a prospective study of a one-stage technique for managing both telecanthus and ptosis seen in blepharophimosis syndrome. The technique involves carrying out a Y to V medial canthoplasty followed by a frontalis suspension which the authors carry...

The impact of conjunctivochalasis on dry eye symptoms and signs

The study aimed to draw a relationship between conjunctivochalasis and dry eye symptoms via a dry eye questionnaire (DEQ5), as well as signs such as tear osmolarity, tear break up time, corneal staining, Schirmer score, meibomian gland dropout, eye lid...

Postural control in glaucoma patients with virtual reality

The authors report on a cross-sectional study evaluating postural control and history of falls in glaucoma patients. History of falls was obtained using the Falls Screening and Referral Algorithm. Postural stability was assessed using a force platform under four conditions:...

IO surgery

The purpose of this paper was to evaluate the efficacy of a new surgical technique in reducing inferior oblique muscle overaction (IOOA) consisting of suturing the muscle to the sclera at the Gobin point with tendon sparing and using a...

Do operative interventions for IIH improve visual function?

The authors of this paper reviewed patient case notes to determine visual outcome following shunt surgery for idiopathic intracranial hypertension (IIH). A retrospective case notes review was conducted for 50 patients who underwent shunt surgery for IIH. Outcome measures included...

Assessing the quality of scars from incisions made by a Colorado needle or a scalpel

Traditional teaching has held the best scars are achieved with cold steel although no previous study has formally investigated this hypothesis in oculoplastic surgery. This paper describes a non-randomised cross-sectional study comparing the scar quality achieved from cold steel with...

Resolution of mid-peripheral schisis in x-linked retinoschisis with the use of dorzolamide

X-linked retinoschisis (XLRS) is an early onset hereditary retinal dystrophy. It is caused by mutations of the RS1 gene. Common manifestations of XLRS are schitic lesions at the macula, as well as infero-temporal schisis. Carbonic anhydrase inhibitors have previously been...

MicroRNA inhibits corneal neovascularisation

MicroRNAs (miR) are small non-coding RNA that target mRNA for destruction. MiR target about 30% of the protein coding genes and fine tune their expression. MiR have been shown to be involved in several cellular processes including cell cycle, tissue...