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Immunoglobulin G4-related ophthalmic disease – what is it? (Part 1)
Part 1: Epidemiology, classification, radiology, histopathology and associations (see Part 2 here) In this two-part series, Li Yen Goh reviews IgG4 disease and reminds us of diagnostic challenges faced. Introduction Immunoglobulin G4 (IgG4) disease is a recently recognised idiopathic systemic...
Practice patterns of uveal melanoma management with Iodine-125 brachytherapy
With the 2006 Collaborative Ocular Melanoma Study Group (COMS) study demonstrating no difference in survival outcomes for participants randomised to either iodine-125 brachytherapy or enucleation, the majority of primary uveal melanomas in the United States are now treated with brachytherapy....
Surgical management options for NLDO
The authors aimed to develop a current collective practice profile for management of nasolacrimal duct obstruction (NLDO). They conducted an online survey of American Association of Pediatric Ophthalmology & Strabismus (AAPOS) members of which 142 completed surveys were collected within...
Endothelial cell loss using different graft injectors in DMEK
This study aimed to investigate endothelial cell loss between two injector systems in descemet membrane endothelial keratoplasty (DMEK) grafts; a glass injector – modified Jones tube and a plastic injector – closed system IOL injector, the Viscoject 2.2 system. DMEK...
What caregivers know about VKC and effect of this on compliance
The authors aimed to determine the knowledge, attitude, and practice among caregivers of children with vernal keratoconjunctivitis (VKC) to assess their level of understanding of the disease and factors that affect compliance with medical advice and compel them to use...
Sickle cell maculopathy
This paper reports the result of a prospective study to analyse the prevalence of sickle cell maculopathy (SCM) and its associations with age, sex, genotype, proliferative sickle cell retinopathy (PSR) stage, and the impact on visual acuity (VA). This study...
Training in Ophthalmology: The Essential Curriculum (second edition)
This textbook was first introduced in 2009, aimed at junior trainees and tailored to fit with the new ophthalmic specialist training (OST) curriculum. The second edition updates the clinical information to reflect changing practice and introduces two new chapters: refractive...The Irlen Experience
My father used to say that humanity is divided into those that see the world through a moral framework and recognise their place within it, and Tories. When a concerned mother came to the paediatric clinic bearing literature from the...In conversation with Robert MacLaren
Professor Robert MacLaren gave the Keeler Lecture at the Royal College of Ophthalmologists Annual Meeting in May 2019 on gene therapy for retinitis pigmentosa. We caught up with him afterwards to find out more. What are the key messages of...
Proof of concept for using aqueous humour to detect retinoblastoma variant
A proof of concept study is presented with the aim of assessing the feasibility of using aqueous humour surrogate marker for tumour tissue for identifying retinoblastoma RB1 variant. Three children undergoing enucleation for retinoblastoma were recruited from a single centre....
Genetic analysis of choroideremia families
Choroideremia (CHM) is a rare X linked recessive chorioretinal dystrophy. Symptoms include nyctalopia and progressive peripheral field loss. Female carriers may have mild symptoms. Choroideremia is known to be caused by a mutation in the CHM gene. A multicentre human...
