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Ranibizumab safety in pregnancy
Vascular endothelial growth factor (VEGF) plays a pivotal role during pregnancy, and systemic anti-VEGF administration during this period should thus be avoided. VEGF is expressed in multiple embryonic and foetal tissues during development, with the highest levels found in the...
Detection of antiranibizumab antibodies in exudative AMD
In this study the authors aimed to detect immune response to ranibizumab treatment in wet age-related macular degeneration (AMD). An ELISA was employed to quantify the anti-ranibizumab titre which was compared against the control anti-abciximab titre. Titres of anti-ranibizumab antibodies...Update on emerging therapies for age-related macular degeneration
The 23rd European Society of Retina Specialists (EURETINA) Congress, held in Amsterdam, the Netherlands, provided a timely update on anti-complement therapy for geographic atrophy and emerging investigational therapies for neovascular age-related macular degeneration. Anti-complement therapy for geographic atrophy Geographic atrophy...
Augmented surgery for monocular elevation deficiency
The outcomes are described for augmented lateral rectus superior transposition in cases of acquired monocular elevation deficiency (MED) associated with large hypotropia in primary gaze. The lateral rectus was transposed superiorly and reinserted on sclera between the temporal margin of...
RTP801 as a neuroprotective and axon regenerative treatment
This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...
IO belly transposition surgery
The authors evaluated inferior oblique (IO) muscle belly transposition to correct mild to moderate IO overaction with small primary position hypertropia. They reviewed 10 patients aged 6-35 years (mean 18.6 years). Aetiologies were mild unilateral superior oblique (SO) palsy for...
A phase 3 randomised trial of nicotinamide for skin cancer chemoprevention
To B3, or not to B3? That was the question asked in this controlled trial in which the authors were able to show that oral nicotinamide (vitamin B3) is able to reduce further skin cancer development in high risk patients....
Intracameral bevacizumab as an adjunct to trabeculectomy
This is a 12-month, prospective, randomised, double-masked, placebo-controlled trial of patients who were not controlled medically with open angle glaucoma and scheduled for a primary trabeculectomy. Patients were recruited and randomised during the period between April 2009 and November 2010....Managing cataract surgery in a patient with diabetic maculopathy
A 56-year-old type 2 diabetic with previously treated bilateral diabetic maculopathy develops a cataract requiring surgery in the right eye. He has had grid laser previously, followed intermittently by intravitreal triamcinalone, Avastin and more recently Lucentis in both eyes. His...
RPE atrophy onset in treated nAMD
In this study the authors aim to evaluate the role of various factors for the development of retinal pigment epithelium (RPE) atrophy over a period of five years in patients with nAMD. Fifty-two newly diagnosed nAMD patients with complete absence...
Acute dacryocystic retention
This is a retrospective study of patients with acute dacryocystic retention (ADR). The condition is distinct from infectious dacryocystitis, and is characterised by an acute onset of pain and epiphora associated with a tender but not inflamed lacrimal sac thought...
