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New study uncovers key mechanism behind a common genetic cause of age-related visual loss
A groundbreaking study has revealed important insights into the mechanisms behind Fuchs Endothelial Corneal Dystrophy (FECD), a common cause of age-related visual loss, providing hope for future therapeutic developments, and finding implications for other neurological diseases. FECD is a common,...
Ozurdex in epiretinal membrane surgery
This was a prospective multicentre pilot study, looking at the effect of Ozurdex on visual acuity (VA) and central retinal thickness (CRT) in patients undergoing surgery for epiretinal membrane (ERM). Twelve eyes of 12 patients were included in the study....Acute dellen formation post trauma
Corneal dellen are saucer-like thinnings, usually of the peripheral cornea [1]. Dellen formation is thought to be related to localised tear film instability [2], specifically the absence of the mucin component of the tear film. Without the mucin layer, dry...Glucose-sensing contact lenses replace the finger prick test!
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are scientific reality and which are ‘fake news’. Headline: Glucose-sensing contact lenses replace the finger prick test! The concept of contact lenses was first illustrated by...Recurrent unilateral preseptal cellulitis secondary to herpes simplex virus infection
Introduction Periorbital (sometimes called preseptal cellulitis) is a common condition which on its own is not normally an ophthalmic or surgical emergency, however it has the potential to cause severe and serious morbidity in cases where the infection has crossed...Serendipity
“Serendipity is looking in a haystack for a needle and discovering a farmer’s daughter” – Julius Comroe Jr (Surgeon, Medical Researcher and Author) One of the attractive features of ophthalmology, apart from the good quality of life and the relatively...Aug/Sep 2017 Quiz
History A seven-year-old atopic boy has been treated for phlyctenulosis with mild topical steroids. However, he developed dramatic changes at the right limbus in two weeks. He also had past history of vernal keratoconjunctivitis (VKC) with poor compliance to treatment....Aug/Sep 2015 Quiz 1
History A 60-year-old woman was referred to ophthalmology with a suspected left eye choroidal naevus. Visual acuity was unaffected in both eyes and she was asymptomatic. Ocular history and medical history were unremarkable. Questions Figure 1: Fundus photograph. 1. What...
Environmental variations in endophthalmitis
In this retrospective cohort study, the authors looked at seasonal and environmental variations in 171 endophthalmitis cases out of 423,297 intravitreal injections. The incidence of this complication was not correlated to monthly snowfall, rainfall, or average temperature. There was no...
ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy
Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...
Somatostatin protects retinal pericytes
Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood sugar levels damaging the retinal microvasculature. Mechanisms, such as oxidative stress and deposition of advanced glycation end products, leads to glial cell activation and neuronal apoptosis. Pericytes, contractile...
