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Regulatory drug evaluations and expedited review initiatives: EU and US perspectives
The European Medicines Agency (EMA) and United States Food and Drug Administration (FDA) each conduct independent assessments of benefit-risk profile when evaluating applications to market new or modified medicines, and their respective decision-making is guided by distinct legislation, procedures and...EU: is it time to leave and embrace the world?
Should the United Kingdom remain a member of the European Union (EU) or leave? It’s a big decision involving some complex issues, and there’s no doubt the EU will continue to change. Ipsos MORI’s monthly EU voting intention poll published...The management of antiplatelets and anticoagulation in elective ophthalmic surgery
Clinical scenario: A 57-year-old gentleman who is scheduled to have Mohs micrographic surgery and reconstruction for a medial canthal basel cell carcinoma (BCC) has been started on aspirin and clopidogrel following a coronary stent three weeks ago. Does the antiplatelet...A Nightmare on Doctor Street: Two
Just when you thought it was safe to go back into the clinic room… The quote below comes from Rudy Baylor, a graduate fresh out of law school and recruited by a ruthless ambulance chaser in the legal drama movie,...Haag-Streit offers free downloadable breath shield template
Haag-Streit has offered users a free downloadable breath shield template for its slit lamps.
Congenital aniridia with or without retinal detachment
The authors present the clinical and molecular genetic evaluations performed on a large Iranian pedigree with 26 aniridia affected patients in four generations and some with retinal detachment. Members of the family affected with aniridia were invited to participate after...
Myopia rate of change from 5-20 years
Data was collected from the 2008-12 KNHANES survey and the study included 7695 of 9351 subjects with refractive data. The mean age was 11.8 years (5-20 range) with 48.2% female. Mean spherical equivalent was -1.82 ±2.23D. For five-year-olds, the mean...
Transconjunctival eyelid weight insertion
This is a description of a new surgical technique to insert upper lid weights via a posterior, transconjunctival route. Following local anaesthetic, the upper lid was everted over a Desmarres retractor with a silk traction suture. A 5mm high central...
BESTi: a new index to detect subclinical keratoconus
In this multicentre, case-control study, the authors develop a new index, named Boosted Ectasia Susceptibility Tomography Index (BESTi), to detect early cases of keratoconus. This index was derived from multiple logistic regression analysis of 22 variables of tomography scans. The...
Modified technique in place of ultrasound biomicroscopy
The authors describe a modified immersion B-scan ultrasonography that includes a standard B scan probe of 10MHz, a surgical glove and sterile saline to fill a finger of the surgical glove – tied off to create the desired immersion standoff...
Keratoconus cone variants
This retrospective study examined correlation between three keratoconic parameters to further understand anatomy of keratoconic cones. Kmax and pachymetry of the thinnest point were obtained from the Pentacam scans. Decentration was calculated as distance from the corneal vertex to the...
