You searched for "epithelium"
Dramatic myopic shift due to epithelial basement membrane dystrophy
3 October 2024
| Annes Ahmeidat, Blazej Staniszewski, James Welch
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EYE - Cornea
Epithelial basement membrane dystrophy (EBMD), also known as map-dot-fingerprint dystrophy, is a common anterior corneal disorder affecting approximately 2% of the population [1]. It is characterised by the abnormal maintenance of the basement membrane, resulting in protrusions into the epithelium....
Retinoblastoma chemotherapeutic drugs and their toxic effects on RPE cells
1 October 2016
| Bheemanagouda Patil
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Retina / Uvea / Vitreous
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chemotherapy, intra-ocular tumour, retinal pigment epithelium, retinoblastoma, toxicity
There is reported clinical evidence of retinal pigment epithelium (RPE) alterations after intra-arterial (IAC) and intravitreal chemotherapy (IViC) of retinoblastoma. The purpose of this study was to investigate the cellular toxic effects of melphalan, topotecan and carboplatin on the RPE...
Microbiology, risk factors and outcomes of microbial keratitis in Sydney, Australia
5 February 2020
| Kurt Spiteri Cornish
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EYE - Cornea, EYE - General
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Microbial keratitis, cornea, dry eye, keratitis, ocular surface disease
The authors present a retrospective case series including all patients with microbial keratitis and ocular surface diseases (OSD), including dry eye, blepharitis, Stevens-Johnson syndrome and / or ocular cicatricial pemphigoid, over a five-year period between 2012 and 2016. A total...
Corneal tattooing as treatment for bullous keratopathy
This retrospective study looked at differences in epithelial smoothing in patients with bullous keratopathy (BK) undergoing either corneal tattooing or anterior stromal puncture (ASP). Both procedures were carried out for symptomatic relief in eyes with poor visual potential. Chinese ink...
Biopsy of nasolacrimal duct using sheath guided dacryoendoscopy
1 August 2019
| Rina Bhatt
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EYE - Neuro-ophthalmology
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Dacryoendoscopy, biopsy, immunohistochemistry, nasolacrimal duct obstruction, sheath-guided endoscopic probing (SEP)
In this study the author’s biopsied six eyes of five individuals with recurrent nasolacrimal duct obstruction following a prior dacryoendoscopic probing. All procedures were performed under local anaesthetic, the obstruction or lesion was directly visualised with dacryoendoscope and biopsy was...
Therapeutic ocular surface medium for persistent corneal epithelial defect
Corneal ulcers and persistent epithelial defects (PEDs) are caused by a variety of different insults to the cornea, which includes limbal epithelial stem cell failure. PED may be resistant to healing with standard therapy such as frequent ointments and /...Understanding amniotic membrane grafts
Safa Elhassan gives a brief review of amniotic membrane grafts and their application in theatre and clinic-based settings. Amniotic membrane (AM) transplant has been an established adjuvant treatment for many corneal, conjunctival and scleral disorders in ophthalmic clinical practice with...
RPE tears after intravitreal Lucentis
1 February 2017
| Saruban Pasu
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Retina / Uvea / Vitreous
The current hypothesis regarding retinal pigment epithelium (RPE) tears is the contraction and fibrosis in choroidal neovascularisation (CNV) tissue after anti-VEGF therapy can induce rips in the overlying RPE. This South Korean study aimed to identify the association between RPE...
Dec/Jan 2017 Quiz
History An 18-month-old boy presented with a slow growing left anterior orbital lump medially. Examination revealed a palpable mass beneath the skin at the inferonasal aspect without any visual impairment. A CT scan (Figure 1) followed by an excisional biopsy...The embryology of the eye
1 December 2015
| Jacob Cook
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EYE - Cataract, EYE - Cornea, EYE - General, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Orbit, EYE - Oncology, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
Nobody claims to like embryology. At least nobody I know. It has been a neglected part of the curriculum since time immemorial and a vicious cycle occurs in which those with an incomplete understanding fail to appreciate the inherent beauty...
Transfected RPE cells inhibit AMD in rats
1 August 2015
| Graham Wallace
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Choroidal neovascularization, Fibulin-5, Retinal pigment epithelium, Transplantation
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...
Treatment of progressive keratoconus
2 August 2024
| Fiona Rowe (Prof)
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Paediatric Ophthalmology / Strabismus
This study aimed to analyse the clinical results of accelerated iontophoresis-assisted epithelium corneal cross-linking (i-ON CXL) to evaluate the risk factors for keratoconus progression after treatment, and the safety and efficacy of re-treatment using epithelium-off CXL protocol in paediatric patients....
