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Seminars in Ophthalmology journal cover image

Intravitreal Ziv-Aflibercept: safety analysis

7 December 2020 | | Retina / Uvea / Vitreous | Diabetic macular edema (DME), Intravitreal ziv, aflibercept (IVZ), Neovascular age related macular degeneration (n, AMD), Ziv, aflibercept, retinal venous occlusion (RVO)
Ziv-Aflibercept (Zaltrap; Sanofi-Aventis U.S LLS, Bridgewater, NJ) was originally introduced as an intravenous formulation for metastatic colorectal cancer. The adoption of Ziv-Aflibercept in ophthalmic practice was similar to bevacizumab, and reports have previously examined one to two year visual outcomes...

OCT biomarkers in asymmetric anti-VEGF response in bilateral diabetic macular oedema

1 December 2021 | | Retina / Uvea / Vitreous | Diabetic macular edema, aflibercept, optical coherence tomography, predictive, ranibizumab
This study aimed to identify optical coherence tomography (OCT) biomarkers for predicting response to anti-VEGF treatment in diabetic macular oedema (DMO). Bilateral DMO patients with asymmetric response to a loading dose of anti-VEGF (ranibizumab / aflibercept) treatment were retrospectively studied....

OCT in proliferative diabetic retinopathy

1 December 2017 | | Retina / Uvea / Vitreous
This report set out to describe the anatomical relationships between retinal neovascular complexes (NVC), the posterior vitreous, and the vitreoretinal interface in patients with proliferative diabetic retinopathy using spectral domain OCT. The following was recorded for each NVC 1) posterior...

Internal limiting membrane (ILM) peeling on blood flow in diabetic macula

2 February 2024 | | Retina / Uvea / Vitreous | Diabetes, Epiretinal membrane, Inner limiting membrane, vessel density, vessel length density
This is a retrospective review of notes for diabetic patients with epiretinal membrane (ERM) who underwent surgery by the same surgeon. Nineteen had ERM peeling only, while the remaining 18 had both ERM and internal limiting membrane (ILM) peeling. The...

NEOS (North Of England Ophthalmological Society) Spring Meeting 2024

23 April 2024
by Matthew Hartley, Trainee, Northern Deanery, UK. In NEOS’ 110th year, the spring meeting was held in Doncaster and centred around ocular oncology and vitreoretinal surgery. The meeting hosts, Umi Harley and Steve Winder from Royal Hallamshire Hospital, arranged a...

Diary from my elective: a Parisian experience

2 December 2019 | | Ophthalmology
The author explains how a research institute’s dedication to multidisciplinary collaboration helped him to discover a passion for academic ophthalmology. The elective aspect to the final year of a medical degree, through its change of scenery and immersion into another...

The interpretation and use of ultrasound biomicroscopy (part 1)

1 October 2016 | | Cornea / External Eye Disease, Imaging, Retina / Uvea / Vitreous
Ultrasound Biomicroscopy (UBM) has become increasingly important for the diagnosis of a variety of anterior segment pathologies. Most ophthalmologists are familiar with conventional B-scan ultrasonography techniques, which operate at lower sound frequencies (7.5 to 20MHz). UBM is an ultrasound technique...

Acute macular neuroretinopathy

3 April 2024 | | Retina / Uvea / Vitreous, COVID-19
Acute macular neuroretinopathy (AMN) is a rare condition that typically affects young women and presents with photopsia and paracentral scotomata [1]. We describe a case of severe acute macular neuroretinopathy, following Covid-19 infection. A 30-year-old woman presented to the urgent...

What's trending Aug/Sep 2022

2 August 2022 | | Ophthalmology
A round-up of the eye related hot topics that have been trending on social media over the last few weeks. #JustinBieber #RamsayHuntsyndrome #facialparalysis Justin Bieber revealed he has been afflicted by Ramsay Hunt syndrome, and thus has had to cancel...

Sclerochoroidal calcification masquerading as ocular malignancy

5 April 2022 | | Ophthalmology, Retina / Uvea / Vitreous
Case 1 A 68-year-old Caucasian gentleman was urgently referred to eye casualty by his optometrist after seeing an unusual incidental finding of protruding lesions from the retina, suspecting choroidal melanoma. He was asymptomatic and this was his first eye test...

An unusual case of acute retinal necrosis

1 August 2015 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
Case report A 40-year-old Caucasian male presented with a four-day history of redness and progressive painless reduction of vision in the left eye. His visual acuities were 6/4 in the right and 6/36 in the left. The left eye showed...

Another plant-based remedy for the eye?

5 June 2020 | | Ophthalmology, Optometry, Cornea / External Eye Disease, Glaucoma
Simerdip Kaur takes a look at the latest ophthalmology-related news stories and asks which are based on facts and which are ‘fake news’. Headline: Another plant-based remedy for the eye? What do the nicknames Mary Jane, tea, and 420 all...