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RTP801 as a neuroprotective and axon regenerative treatment
This paper describes the neuroprotective and axon regenerative effects of siRTP801, which is a translatable small-interfering RNA (siRNA) targeting mTOR negative regulator; RTP801, through in-vivo and in-vitro models. In-vivo studies involved an optic nerve crush rat model with intravitreal injections...
Outcomes of cataract surgery in patients with uveitis
This is a systematic, evidence-based literature review and meta-analysis, looking at the visual outcomes (vision 20/40 or better) of cataract surgery in uveitic eyes. The authors searched MEDLINE, EMBASE, CINHAL and CENTRAL, including English language and human studies only. They...Sustainability in eyecare: Aravind Eye Hospital’s low carbon eyecare system
The field of healthcare has a substantial impact on the environment as it is responsible for 5-10% of greenhouse gas emissions and 9% of air pollutant generation [1]. Surgery is associated with the rapid consumption of single-use products and waste...
Management of diabetic macular oedema (DMO)
The authors present guidelines on current diagnostic and therapeutic procedures in the management of DMO. Fluorescein angiography (FA) and optical coherence tomography (OCT) are recommended before starting treatment to help diagnose and stage DMO, and can be repeated if there...Ophthalmology Scholarship Applications Open – Deadline 1 June 2021
The University of Edinburgh has opened applications for The David and Molly Pyott Foundation Scholarships in Ophthalmology which will support eligible ophthalmology trainees / registrars /residents undertake the university’s online, two-year, part-time ChM (Master of Surgery) in Clinical Ophthalmology from September 2021.
Retinal vessel diameter in pseudoexfoliation
Pseudoexfolation (PEX) is characterised by deposition of fibrillary extracellular material on ocular and extraocular tissue. Studies have shown that deposition in vascular structures cause hypoxia and ischaemia. In the eye, a decrease in blood supply to the optic nerve can...
Benefit of selenium and vitamin D supplementation in thyroid eye disease
There is some limited evidence of as association between thyroid eye disease (TED) and nutritional deficiencies including selenium and vitamin D. Prior studies show that selenium can reduce TPO-antibody concentrations and improve hypothyroidism and post-partum thyroiditis. Limited evidence also shows...
Investigating the effect of signal strength on mean retinal nerve fibre layer
The aim of this study was to determine the effect of signal strength on mean retinal nerve fibre layer (RNFL) using spectralis optical coherence tomography (S-OCT). Thirty normal subjects were imaged with S-OCT using variably dense Bangerter foils to alter...
Secondary glaucoma post paediatric cataract surgery
This retrospective observational consecutive case series assessed the incidence and risk factors associated with developing glaucoma after paediatric cataract surgery with primary intraocular lens (IOL) implantation. They reviewed 136 children (199 eyes) who underwent paediatric cataract surgery before the age...
Complications after cataract surgery in high myopes: a systematic review and meta-analysis
The authors review all the modern literature on complications after phacoemulsification in high myopes with axial lengths (AL) greater than 25.0mm. Twenty-eight studies reporting on 19,586 eyes were included. The corrected distance visual acuity (CDVA) improved from 0.96 ± 0.53...
Using optical coherence tomography angiography to detect MoyaMoya vasculopathy
Moyamoya (MM) disease is a chronic cerebrovascular disease that can lead to progressive stenosis of the terminal portions of the internal carotid arteries and their proximal branches. The authors carried out a cross-sectional cohort study to investigate vascular changes in...
