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HtrA1 enhances cell senescence

1 December 2013 | | Retina / Uvea / Vitreous
A genetic basis for age-related macular degeneration (AMD) has been greatly advanced in recent years. The role of identified pathways such as complement factor H in AMD has been widely investigated. However, the effect of other gene variants identified by...

Pituitary tumours: why are they so often missed?

1 April 2017 | | Neuro-Ophthalmology
Part 1: Introduction, historical background and Edinburgh connections (see also Part 2 and Part 3) Is there any ophthalmologist who has not missed a pituitary tumour? Hopefully this article will help those currently in practice to avoid such an embarrassment,...

A novel integrated practice unit (IPU) approach to periocular skin cancer management

4 December 2023 | | Oculoplastics, COVID-19
The COVID-19 pandemic was one of the biggest challenges to face NHS workers. However, history has repeatedly shown that times of difficulty can result in the development of significant social and technological advances. We describe our own experience of this...

Management of diabetic macular oedema in vitrectomised eyes

1 August 2016 | | Retina / Uvea / Vitreous
Diabetic macular oedema (DMO) is one of the leading causes of blindness; its prevalence is on the rise with progressive increase in numbers of people suffering from diabetes. The management of DMO has evolved significantly over the past few years....

What’s next in retinal imaging? Faster, deeper and full-on

1 April 2015 | | Retina / Uvea / Vitreous, Imaging
Fast-evolving technological leaps are opening the way toward clinically useful ocular coherence angiography, generating 3-dimensional microvasculature maps without intravenous dye injection, as well as whole-eye imaging, handheld patient-operated optical coherence tomography (OCT) devices and, for challenging vitreoretinal procedures, integrated intraoperative...

Renewed momentum in ocular gene and cell therapy, broadening application to chronic disease

5 February 2020 | | Ophthalmology, Retina / Uvea / Vitreous
Gene and cell therapies offer the prospect of ground-breaking new avenues for the treatment of diseases, reflected in a renewed explosion of interest and investment in retinal gene therapy. Rod McNeil reports recent clinical trial readouts across a diverse range...

The management of retinal vein occlusions: a summary

1 February 2015 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Imaging, Ophthalmology, Retina / Uvea / Vitreous
Retinal vein occlusions (RVO) are the most common cause of visual loss from retinal vascular disease second to diabetic retinopathy. Vision is lost due to ischaemia, macular oedema and / or haemorrhage which ultimately effects a patient’s quality of life...

Understanding and confronting bacterial endophthalmitis

2 December 2019 | | Ophthalmology, Cornea / External Eye Disease, Emergency Ophthalmology, Retina / Uvea / Vitreous
Abdus Samad Ansari highlights the importance of early recognition of this condition using an unusual presentation. Endophthalmitis is a medical emergency with devastating consequences. Despite adequate treatment, severe cases frequently result in permanent blindness. Endophthalmitis involves inflammation of both the...

The paediatric cataract: an overview of the diagnosis and management

5 August 2020 | | Ophthalmology, Cataract and Refractive
In this second article (see first article here), Samuel Aryee and Rhys Dumont Jones review the challenges involved in managing this condition. Examination and diagnosis Cataracts in children can appear in a variety of forms, each presenting in a different...

Cancer associated retinopathy

7 December 2020 | | Ophthalmology, Retina / Uvea / Vitreous
Abdul Muhyemin Tarin reviews the presentation, pathophysiology and management of this paraneoplastic syndrome. Case presentation A 60-year-old hypermetropic female patient presented with several months’ history of painless blurred vision. Visual acuity (VA) was 6/24 and 6/9-1 in right and left...

The bionic eye – behind the headlines

1 October 2016 | | Oculoplastics, Orbit
Multiple visual prosthetic projects and other vision regeneration initiatives being tested in preclinical and clinical development worldwide illustrate continuing progress and opportunities in addressing profound blindness from hereditary retinal diseases and other causes (Table 1). Three implantable bionic vision systems...

Infection prevention and control through a VISION 2020 LINK between Mombasa and Southampton

1 April 2017 | | Cataract and Refractive, Cornea / External Eye Disease, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous, AMD, Emergency Ophthalmology
The authors share how a partnership between Mombasa and Southampton has enabled Kenyan healthcare professionals from four institutions to innovate and work as a group to improve infection prevention and control. Infection prevention and control (IPC) is a cornerstone of...