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G-CSF intravitreal injections for NAION: a pilot study

5 April 2022 | | Neuro-Ophthalmology | Anterior ischemic optic neuropathy, Granulocyte colony-stimulating factor, Intravitreal injection, Neuroprotection, Optic atrophy
In rodent models with anterior ischemic optic neuropathy (AION), granulocyte colony-stimulating factor (G-CSF) confers a neuroprotective effect on retinal ganglion cells (RGCs) via anti-apoptotic and anti-inflammatory processes. This prospective study investigated the efficacy of intravitreal injection of G-CSF for the...

Visual prognosis in Irish Leber’s hereditary optic neuropathy

1 December 2022 | | Neuro-Ophthalmology | Leber’s hereditary optic neuropathy, idebenone, inherited optic neuropathy, mtDNA, ophthalmic genetics, optic atrophy
Leber’s hereditary optic neuropathy (LHON) is an inherited optic neuropathy This paper presents a retrospective review of clinical data from patients with LHON presenting to an Irish tertiary referral ophthalmic hospital. Clinical and genetic characteristics were assessed for useful biomarkers...

Non-arteritic anterior ischaemic optic neuropathy in the Asian population

1 October 2014 | | Neuro-Ophthalmology | Ischaemic optic neuropathy, visual acuity, visual fields
This article provides an evaluation of changes in visual function associated with non-arteritic anterior ischaemic optic neuropathy (NAION) among Korean patients. Visual changes were identified as a reduction in visual acuity by three Snellen lines or a deterioration of visual...
American academy of Ophthalmology book cover

American Academy of Ophthalmology – Updated textbooks Basic and Clinical Science Course 2018-2019

1 October 2019 | | Ophthalmology, Neuro-Ophthalmology
The American Academy of Ophthalmology publish a series of books entitled Basic and Clinical Science Course every year. It’s a highly regarded series and has often been quoted to me as a good reference set of books. Indeed, I invested...

Toxic nutritional optic neuropathy (TON)

2 August 2022 | | Ophthalmology
Toxic optic neuropathy are a group of conditions manifested by reduction of visual functions secondary to damage to the anterior visual pathways from exposure to a toxin. The implicated toxin could be work-based, food or drink related, or iatrogenic medication....

Review of non-arteritic anterior ischaemic optic neuropathy

1 October 2016 | | Neuro-Ophthalmology | Neuroprotection, optic nerve ischemia, optic nerve vasculature, primate models, rodent models
This article reviews the risk factors, clinical presentation and therapies that have been investigated for non-arteritic anterior ischaemic optic neuropathy (NAAION). Additionally, it provides an update from recent rodent and primate models, offering a new insight into the pathophysiology of...

Rare eye diseases: progress continues with authorised orphan medicines and breakthrough technologies

1 October 2018 | | Ophthalmology
An update on the development of orphan medicines, recent regulatory treatment approvals for rare eye conditions and advances in retinal prosthetic technologies for blinding diseases. The prevalence of a rare disease is based usually on a range of estimates and...

Quality matters in the management of serious eye disorders

1 June 2019 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
The author discusses the first quality standard for serious eye disorders from NICE and takes a look at new care models for enhanced service delivery. Patient backlogs pose risks to patient safety, with research showing that people are losing sight...

Eye research: where next?

1 December 2017 | | Cornea / External Eye Disease, Cataract and Refractive, Glaucoma, Genetics, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous, AMD, Emergency Ophthalmology
Eye research in the UK is underfunded relative to other areas of medical research and general awareness of sight loss and its prevention remains poor, messages that were reinforced in presentations and discussions during a recent research summit meeting in...

25 years of OCT

1 December 2016 | | Retina / Uvea / Vitreous, Imaging
David Huang first described optical coherence tomography (OCT) in 1991, in his seminal paper on the subject in Science. This method developed the work of others on ophthalmic interferometry, which essentially showed that measuring reflected light could be used to...

The Global Vision Database

1 December 2015 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Oculoplastics, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
The overall goal of the Global Vision Database (GVD) [1] is to develop and deploy new and improved evidence on the prevalence of blindness and vision impairment (VI) globally. It is a repository which allows us to assess the causes...

Initiatives in macular service provision

1 December 2015 | | Retina / Uvea / Vitreous
A report from Monitor in October 2015 identifies good practices that will realise most of the potential productivity gain in elective care available to NHS hospitals. These include: stratifying patients by risk and creating low-complexity pathways for lower-risk patients (tailoring...