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Gene therapy for inherited retinal disease: the Manchester Ocular Gene Therapy Group MDT service

4 August 2021 | | Ophthalmology, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
The authors describe the process set up in Manchester for the optimum delivery and assessment of a new gene therapy treatment for patients with RPE65 IRD. Inherited retinal dystrophies (IRDs) are the second commonest cause of severe visual impairment in...

Sustainability in eyecare: Intraocular gases and the climate emergency

4 August 2021 | | Ophthalmology, Retina / Uvea / Vitreous
In 2020 the NHS became the first national health system to commit to delivering ‘net zero’ carbon emissions by 2040. The author investigates how the impact of ophthalmic surgery can be reduced. Medical gases have been used in ophthalmic surgery...

Optical coherence tomography – reinventing the eye examination

1 October 2016 | | Retina / Uvea / Vitreous, Imaging
It has been 25 years since Huang et al. presented the first optical coherence tomography (OCT) images in Science [1]. With vast improvements in OCT technology over the years, it is now possible to acquire high-resolution cross-sectional images of the...

Grading of ocular inflammation in uveitis: an overview

1 February 2016 | | Retina / Uvea / Vitreous
Anterior uveitis is the commonest form of uveitis, which can lead to severe morbidity if not treated appropriately [1]. Data from general ophthalmology practices suggest around 90% of uveitis encountered by comprehensive ophthalmologists is anterior uveitis [2]. Intermediate (vitreous), posterior...

PACK-crosslinking for infectious keratitis

1 October 2015 | | Cornea / External Eye Disease
Corneal cross-linking with riboflavin and UV-A light (CXL) is a technology that has been initially developed to treat corneal ectatic disorders [1]. Its effect in stabilising diseases such as keratoconus was reported in numerous trials with excellent long-term outcomes and...

Assessing everyday visual function in dry AMD – what matters to the person?

1 April 2019 | | Retina / Uvea / Vitreous, AMD, Ophthalmology, Optometry
Age-related macular degeneration (AMD) is the primary cause of blindness in the developed world and is accountable for more than one half of sight impairment registrations within England and Wales [1]. AMD is prevalent in people aged 60 years and...

The treachery of images – making sense of OCT imaging

1 June 2016 | | Retina / Uvea / Vitreous, Imaging
In 1929 Belgian surrealist Rene Magritte produced his painting La Trahison des Images. It depicted an old fashioned pipe for smoking tobacco and underneath were the words “ceci n’est pas une pipe”, this is not a pipe. You may wonder...

Lessons from an unusual case of syphilis

3 August 2023 | | Retina / Uvea / Vitreous
The rise of syphilis transmission rates over the past two decades has been one of public health’s great puzzles. In the UK, the situation has reached epidemic levels, with a 126% increase between 2013 and 2018 [1]. We present a...

A glossary

5 October 2020 | | Ophthalmology, Optometry
After a week on call grading what feels like 13 billion referrals I decided it might be useful to come up with a glossary that might help other people in some way to decipher the true meaning behind every repetitive...

What's trending Dec/Jan 2019

1 December 2018 | Ophthalmology, Orbit, Emergency Ophthalmology, Cataract and Refractive, Retina / Uvea / Vitreous
On the first day of Christmas, my true love gave to me…A #RyderCup globe injury An unfortunate spectator was hit in the eye by a wayward golf ball during the Ryder Cup, and suffered, as she called it, “a fracture...

“Beware of the pigment”

4 August 2021 | | Ophthalmology, Glaucoma
Using some captivating artwork, Iheukwumere Duru describes key features of pigment dispersion syndrome. Pigmentary dispersion syndrome (PDS) leads to pigmentary glaucoma (PG) in approximately 35-50% of patients with the condition [1]. PG is the leading cause of non-traumatic blindness in...

Corneal transplantation in the United Kingdom: are we blind to the challenges that still exist after the Organ Donation Bill?

28 November 2022 | | Cornea / External Eye Disease, Ophthalmology
Corneal transplantation (CT) is a significant treatment option for a huge number of patients in the United Kingdom (UK) [1]. For an individual, CT results in a substantial improvement in quality of life. Penetrating keratoplasty with full thickness grafting has...