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Injection of methotrexate into silicone oil-filled eyes for grade C PVR

Methotrexate (MTX) is an antineoplastic antimetabolite with immunosuppressant properties. Folate antagonism is known to contribute to the antiproliferative effects of MTX, and release of adenosine from cells and inhibition of polyamines may explain its anti-inflammatory effects. These activities contribute to...

OCT in proliferative diabetic retinopathy

This report set out to describe the anatomical relationships between retinal neovascular complexes (NVC), the posterior vitreous, and the vitreoretinal interface in patients with proliferative diabetic retinopathy using spectral domain OCT. The following was recorded for each NVC 1) posterior...

Retinal structural features of CMV retinitis

Confocal adaptive optics (AO) technology has enabled cellular level retinal imaging, including imaging of photoreceptors and blood flow. Adaptive optics scanning laser ophthalmoscopy (AOSLO) is a technology that provides high resolution and high contrast retinal images by correcting ocular aberrations....

ICG TTT for retinoblastoma

Transpupillary thermotherapy (TTT) is a specific form of ocular TT using infrared radiation (diode laser). Indocyanine green (ICG) is also used to achieve the optimal phototherapy effect in eyes with minimal pigment. Twenty-one patients with 42 retinoblastomas in 30 eyes...

Effect of topical diclofenac on postoperative PRK pain: RCT

A major disadvantage of excimer laser photorefractive keratectomy (PRK) is pain and discomfort after the surgery, which is thought to be due to damage to corneal sensory nerve fibres or local release of inflammatory substances. Pain only resolves once corneal...

Intravitreal dexamethasone implant for diabetic macular oedema

The authors report on the three-year outcomes of the Ozurdex Dexamethasone (DEX) intravitreal implant multi-centre trial for the treatment of diabetic macular oedema (DME). Patients with DME (best-corrected vision of 20/50 to 20/200 and central retinal thickness of ≥300µm) were...

Swept-source OCT for measuring peripheral anterior synechiae

The authors report on a cross-sectional study looking at swept-source optical coherence tomography (SS-OCT) for measuring the area and degree of peripheral anterior synechiae (PAS) in patients with angle closure glaucoma. The SS-OCT is commercially available, has a laser wavelength...