You searched for "Gene therapy"
RPE tears in cases of IPCV
1 April 2020
| Saruban Pasu
|
Retina / Uvea / Vitreous
The aim of this study was to investigate the occurrence, characteristics, management and prognosis of retinal pigment epithelium (RPE) tears in patients with polypoidal choroidal vasculopathy (PCV). Medical records of previous cases were reviewed over an eight-year period from a...
Subthreshold micropulse laser in BRVO
1 August 2019
| Saruban Pasu
|
Retina / Uvea / Vitreous
The purpose of this retrospective, consecutive, single-centre, non-randomised, and case-control study was to verify the therapeutic effects and safety of oedema (from branch retinal vein occlusion (BRVO)) recurrence suppression effect using 577-nm subthreshold micropulse laser photocoagulation (SMLP) in combination with...
Macular atrophy with aflibercept
1 October 2018
| Saruban Pasu
|
Retina / Uvea / Vitreous
The authors of this paper set out to investigate the prevalence of macular atrophy in treatment-naive patients with neovascular AMD undergoing aflibercept monotherapy (three monthly loading injections followed by subsequent treatment every two months). Case notes over a three year...
Adjunctive topical 5-FU vs. MMC for surgically excised, localised OSSN
1 October 2014
| Anjali Gupta
|
EYE - Cornea, EYE - General
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OSSN, chemotherapy, ocular oncology, ocular surface tumours
Ocular surface squamous neoplasia (OSSN) comprises a range of dysplasia including corneal-conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma. The traditional treatment for localised non-invasive OSSN has been surgical excision with or without intraoperative cryotherapy. Postoperative adjunctive topical chemotherapy significantly...
Reduction of severe visual loss and complications following IAC for RB
1 October 2018
| Jonathan Chan
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Retina / Uvea / Vitreous
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Child health (paediatrics), Electrophysiology, Neoplasia, Retina, Vision
This was a retrospective cohort study of patients with retinoblastoma (RB) who required intra-arterial chemotherapy (IAC) between 2013 and 2015, who had relapsed following systemic chemotherapy. A total of nine patients were included in the study and their ocular complications...
OCT use with macular retinoblastoma
1 April 2015
| Fiona Rowe (Prof)
|
Paediatric Ophthalmology / Strabismus
The authors explore the use of portable hand-held spectral domain OCT (SD-OCT) in three eyes of three infants and young children with macular retinoblastoma. All were treated with chemotherapy and all had SD-OCT before and after treatment. The children were...
Orbital rhabdomyosarcoma treatment characteristics
1 February 2017
| Fiona Rowe (Prof)
|
Paediatric Ophthalmology / Strabismus
The aim of this study was to review the clinical presentation, management, local and systemic outcomes of 14 orbital rhabdomyosarcoma (OR) cases with the focus on the role of surgery as treatment. The mean age at presentation was eight years...
Using a tumour registry to investigate optic nerve gliomas
31 October 2023
| Lauren R Hepworth
|
EYE - Neuro-ophthalmology
This study is a retrospective comparative analysis. Patients with optic nerve glioma and pilocytic astrocytoma were identified through the Surveillance, Epidemiology and End Results (SEER) cancer registry covering a 42-year period using standardised codes. The following data was extracted: basic...
Carcinoid tumours
This is a retrospective review of 28 patients with carcinoid tumours affecting the orbit. The mean age at presentation of the orbital involvement was 62 years, with a slight female preponderance, and 21% had carcinoid syndrome. Proptosis and diplopia were...The presentation of natural killer / T cell lymphoma to the oculoplastic surgeon
The authors present three cases of periorbital extranodal natural killer / T cell lymphoma (ENKL). Ages were 20, 45 and 55. All of these patients presented with painless eyelid swelling and a history of sinus disease. One patient had persistent...Complications with porous orbital implant after enucleation in retinoblastoma patients
1 April 2019
| Rina Bhatt
|
EYE - Orbit
This is a retrospective, case control study aimed to identify risk factors associated with complications in retinoblastoma patients following primary and secondary enucleations with porous implant placements. Patients with retinoblastoma who underwent enucleation with porous orbital implant placement between January...
Considerations in the management of retinal disorders
1 October 2017
| Rod McNeil
|
EYE - Vitreo-Retinal
Vision research presentations and publications explore practice considerations in the management of AMD and diabetic retinopathy. Over the past two decades in Europe there has been a decreasing prevalence of age-related macular degeneration (AMD) and an improvement in visual acuity...