You searched for "diabetes"
100 years of insulin
3 October 2022
| Aaron Carlisle, Kieran Walshe, Lloyd Paul Aiello (Prof), Tunde Peto, Katie Curran
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Ophthalmology
*Joint first authors The centenary of the discovery of insulin is a time to celebrate one of the most significant scientific discoveries of the 20th century. Background Before 1923, Type 1 diabetes mellitus [T1DM] resulted in death from severe ketoacidosis...
Prevalence of acute anterior uveitis in diabetic patients attending diabetic eye disease clinics
The authors share their investigation at Manchester Royal Eye Hospital into the association between diabetes and AAU. The global prevalence of diabetes mellitus (DM) is rapidly rising from an estimated 9.3% in 2019 to 10.2% by 2030 [1]. The link...Fundus photography in Malawi – setting up a screening programmefor diabetic retinopathy
1 August 2016
| Frederick Burgess, Joseph Msosa, Caroline Styles
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Cataract and Refractive, Cornea / External Eye Disease, Genetics, Glaucoma, Imaging, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Neuro-Ophthalmology, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous, AMD, Emergency Ophthalmology
We present the case of a 53-year-old lady who presented to the diabetes outpatient clinic at Kamuzu Central Hospital (KCH), Lilongwe, Malawi. She was diagnosed with type 2 diabetes mellitus six years ago, for which she takes metformin orally. She...
Akimba mice, a model of human diabetic retinopathy
1 October 2014
| Graham Wallace
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Retina / Uvea / Vitreous
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Akimba, BRB, PLVAP, blood-retinal barrier, diabetic macular edema, diabetic retinopathy, mouse models, retina
Diabetic retinopathy (DR) is a major complication of diabetes and a growing problem as the systemic disease becomes more prevalent. DR develops insidiously from an asymptomatic form through to vascular damage that leads to oedema and breakdown of the blood-retinal...
Tackling diabetic retinopathy globally through the VISION 2020 LINKS Diabetic Retinopathy Network
1 February 2017
| Nick Astbury, Philip Burgess, Allen Foster (Prof), Denise Mabey, Marcia Zondervan
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Genetics, Ophthalmology, Optometry, AMD, Emergency Ophthalmology, EYE - Cataract, EYE - Cornea, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
It is abundantly clear that the burden of diabetes is rapidly increasing, as there are now 415 million adults with diabetes in the world, with a projected rise to 642 million by 2040 [1]. This equates to 1 in 10...
ANGPTL-4 inhibition reduces inflammation in diabetic retinopathy
1 June 2018
| Graham Wallace
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Retina / Uvea / Vitreous
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Adipocytokine, Angiopoietin-like protein-4 (ANGPTL-4), Diabetic retinopathy (DR), Hypoxia inducible factor-1 alpha (HIF-1α), Inflammation, Profilin-1
Diabetic retinopathy (DR) is the most common cause of blindness in working-age humans, and numbers are rising due to increased cases of type 2 diabetes (T2D). T2D is associated with increased obesity and dyslipidaemia, which is a major risk factor...
A near miss
A 55-year-old gentleman presented with a ‘blurry patch’ to his left eye which he had noticed for the past two months. The visual acuity with correction was 6/5 in the right eye and 6/6 in the left eye on the...Inflammation and microvascular changes in diabetic retinopathy
1 February 2022
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
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Aqueous flare, diabetes mellitus, diabetic retinal neuropathy, diabetic retinopathy, intraocular inflammation, neuroinflammation
Studies have shown that neurodegeneration and inflammation in the retina start early in diabetic retinopathy (DR) and can be present before the latter is clinically evident. The aim of this retrospective review of 99 diabetic patients was to evaluate retinal...
WATCH: Novel imaging technology reveals role of immune cells in early diabetic cataract development
In this video interview, Proffessor Ali Hafezi-Moghadam and Professor Dr. Christoph Rußmann discuss their findings on the role of immune cells in early diabetic cataract development.Orbis named winner of 2023 Amazon Web Services IMAGINE grant for non-profits
Orbis will work with Amazon's cloud computing arm to expand access to artificial intelligence-assisted eye screenings in Asia and Africa.Collaborating across the Caribbean to tackle diabetic retinopathy
1 December 2017
| Pippa Williams, Melissa Bailey, Covadonga Bascaran, Marcia Zondervan
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AMD, Emergency Ophthalmology, EYE - Vitreo-Retinal
The VISION 2020 LINKS Programme has been running since 2004, with a focus on improving the quality and quantity of eye care training in low-income countries [1]. In 2014, the Diabetic Retinopathy Network (DR-NET) was established [2]. This is a...
A possible biomarker for diabetic retinopathy
1 August 2017
| Graham Wallace
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Retina / Uvea / Vitreous
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Alternative splicing, Delta-1, Diabetic retinopathy, RNA expression, Tubulin, Whole transcriptome analysis
Diabetic retinopathy (DR) is the most common form of diabetic eye disease, characterised by exudates, microaneurysms and haemorrhage. Early diagnosis is crucial for preventing visual loss. The risk of developing diabetic retinopathy is known to increase with age as well...