You searched for "child"
Non-organic visual loss
Patients can present to eye departments with various signs and symptoms (mostly symptoms) with no obvious organic cause. These patients can be labelled with any of a wide range of diagnoses such as functional visual loss, functional overlay, psychosomatic reaction...Jury duty
Until a few years ago doctors were exempt from jury duty. I am glad that this exemption was lifted as the stint I did at the crown court in Swansea recently was one of the most illuminating two weeks I...
Screening accuracy
In this study the authors observed whether and how well orthoptic tests are performed by non-orthoptists in a screening setting. They assessed the quality of screening tests by semi-structured observations of youth health care (YHC) physicians who screened children aged...
DIY IOP – does it work?
Measuring intraocular pressure (IOP) plays a major role in glaucoma care as IOP is a parameter, along with visual field progression and optic disc cupping used to assess treatment effect. While Goldmann tonometry (GAT) is the gold standard, it only...
Importing iron to the retina
In the retina, iron is particularly critical for the visual phototransduction cascade. In the retinal pigment epithelium (RPE), RPE65 activity leads to 11-cis-retinaldehyde, the photosensitive component of rhodopsin production and iron containing enzymes are necessary for disc replacement in photoreceptor...
An alternative to povidone-iodine for intravitreal injections?
While povidone-iodine (5% aqueous) preparations have historically been considered the most effective antimicrobial prophylaxis for ophthalmic procedures and have been adopted as routine for intravitreal injections, post-procedure pain is a commonly recognized adverse event of IVI and has typically been...
Differential inhibition of EAU by CTLA4 and IL-6
Cytotoxic T lymphocyte antigen-4 (CTLA4) binds both CD80 and Cd86 and inhibits T lymphocyte activation via CD28. Il-6 is a pleiotropic cytokine that has been associated with many autoimmune conditions including uveitis. Blockade of these molecules by either CTLA4-Ig, a...
MicroRNA mediate retinoblastoma signal transduction
MicroRNAs (miR) are small non-coding single-stranded RNA molecules, normally 22 nucleotides long. There is a large family of miR that control protein expression by binding to mRNAs, leading to their degradation. One important role of miR is in tumours where...
