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Ranibizumab versus laser in diabetic macular oedema (LUCIDATE study)

1 October 2014 | | Retina / Uvea / Vitreous
The aim of this study was to compare the functional and structural effects of Ranibizumab versus macular laser treatment in patients with diabetic macular oedema. It was a single centre, prospective, randomised, single masked clinical trial spanning a 48 week...

Long-term results of cross-linking treatment for keratoconus

1 December 2013 | | Cornea / External Eye Disease
The authors report on the long-term outcomes in a prospective case series of patients with keratoconus undergoing corneal collagen cross-linking (CXL) treatment. Thirty-two patients (40 eyes; mean age 22.5+/-5.5 years) with Grade I, II and III progressive keratoconus were recruited...

Viral conjunctivitis and COVID-19

23 March 2020 | COVID-19
A joint statement was released by the Royal College of Ophthalmologists and College of Optometrists on 19 March.
Neuro-Ophthalmology journal cover image

Amyotrophic lateral sclerosis (ALS): what happens to eye movements?

3 February 2023 | | Neuro-Ophthalmology | Eye movement, amyotrophic lateral sclerosis, anti-saccades; biomarker, pursuit, saccades
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of upper motor neurons of the corticospinal tract and lower motor neurons in brainstem nuclei and the anterior horn of the spinal cord. Limited literature is available on abnormal ocular movements in...

Three years of experience with quantiferon-TB Gold Testing in patients with uveitis

1 April 2015 | | Retina / Uvea / Vitreous | Epidemiology, gamma interferon release essay, infectious uveitis, quantiferon, tuberculosis
Quantiferon-TB Gold is a new alternative to the tuberculin skin test that utilises synthetic peptides representing M. tuberculosis antigens ESAT-6, CFP-10, TB7.7 and upon incubation with whole blood IFN-γ is released from pre-sensitised T cells and can be measured by...

Intravitreal injection related endophthalmitis

1 April 2015 | | Retina / Uvea / Vitreous | Age-related macular degeneration (AMD), endophthalmitis, intravitreal injection, post-injection complications, vascular endothelial growth factor (VEGF)
This article reviews the incidence, clinical findings, risk factors, management and visual outcomes in intravitreal injection related endophthalmitis. Incidence of this complication is reported to be in the range of 0.038% to 0.065% (1 in 2000-3000 injections). Patients present typically...

Is it NAION… Now what?

3 April 2024 | | Neuro-Ophthalmology
Case presentation We present the case and discussion of a 46-year-old Caucasian male who complained of immediate reduced vision following complicated neck dissection including a total laryngopharyngectomy, free flap reconstruction for a T4N3 squamous cell carcinoma (SCC) of the left...

Doctor in the House

4 August 2021 | | Ophthalmology
“What’s the bleeding time?”“10 past 10 sir”. These are the famous lines uttered by Chief Surgeon Sir Lancelot Spratt (James Robertson Justice) and Medical Student Simon Sparrow (Dirk Bogarde) on a pre-op ward round at the fictional St Swithin’s Hospital,...

Brexit, for richer, for poorer: prospects for post-withdrawal Britain

1 July 2017 | | Cataract and Refractive, Cornea / External Eye Disease, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Genetics, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous, AMD, Emergency Ophthalmology
The people of the United Kingdom voted by 52% to 48% to leave the European Union (EU) in June 2016, a referendum decision intended by a slim majority to restore national self-determination and achieve what many believed to be a...

Non-arteritic anterior ischaemic optic neuropathy (NA-AION): a review

1 February 2017 | | Neuro-Ophthalmology
Ischaemic optic neuropathy (ION) is the commonest adult optic neuropathy encountered today in our ageing population, is a common cause of irreversible visual loss and is usually associated with underlying vascular disease. The condition is classified as follows: (a) Anterior...

Grading of ocular inflammation in uveitis: an overview

1 February 2016 | | Retina / Uvea / Vitreous
Anterior uveitis is the commonest form of uveitis, which can lead to severe morbidity if not treated appropriately [1]. Data from general ophthalmology practices suggest around 90% of uveitis encountered by comprehensive ophthalmologists is anterior uveitis [2]. Intermediate (vitreous), posterior...

Lessons from an unusual case of syphilis

3 August 2023 | | Retina / Uvea / Vitreous
The rise of syphilis transmission rates over the past two decades has been one of public health’s great puzzles. In the UK, the situation has reached epidemic levels, with a 126% increase between 2013 and 2018 [1]. We present a...