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Detecting apoptosis in retinal cells

1 February 2022 | | Retina / Uvea / Vitreous | Apoptosis, Glaucoma, Imaging, Neurodegeneration, Retina
This is a review paper in which the authors summarise the transitioning of techniques detecting apoptosis from bench to bedside, along with the future possibilities they encase. Detection of Apoptosis in Retinal Cells (DARC) technology can be used as a...

Unilateral Single Wall Decompression of Thyroid Proptosis Following an Incidental Traumatic Injury

1 December 2013 | | Ophthalmology, Neuro-Ophthalmology
Case report A 69-year-old female with a long history of Grave’s ophthalmopathy was under routine follow-up when it was noted during a clinic visit that the amount of proptosis and lid retraction in her right eye had remarkably reduced. A...

Acetylcholine receptor antibodies in the diagnosis of ocular myasthenia gravis at the Manchester Royal Eye Hospital

3 August 2023 | | Neuro-Ophthalmology
Myasthenia gravis (MG) is the commonest autoimmune condition to affect the neuromuscular junction. In the UK, its prevalence is 15 per 10,000 [1,2] and recent studies have shown that rates are steadily increasing [3,4]. Aims of this audit The aim...

Leber’s hereditary optic neuropathy: from lab to clinic

1 October 2016 | | Neuro-Ophthalmology | Hereditary optic neuropathy, Leber hereditary optic neuropathy, mitochondrial optic neuropathy, optic neuropathy
Leber’s hereditary optic neuropathy (LHON) was the first clinically described mitochondrial disorder (1871). This article reviews the pathophysiology and clinical features of LHON with a focus on translational research. G11778A is currently the most common mutation worldwide and is associated...

The eye without tears

1 June 2016 | | Cataract and Refractive, Cornea / External Eye Disease, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous, AMD, Emergency Ophthalmology
The Art is long and Life is short. So goes the dispiriting tag in Latin and flung from day one and at regular intervals thereafter at idle medical students who, inevitably brainwashed, come by graduation to believe that the only...

Feb/Mar 2014 Quiz 2

1 February 2014 | | AMD, Cornea / External Eye Disease, Cataract and Refractive, Emergency Ophthalmology, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
History A 65-year-old lady presented with a ten year history of nonspecific visual disturbance and mild symptoms of dry eyes. Questioning revealed progressive nyctalopia. Previous medical history of note included Crohn’s disease requiring two bowel resections including small intestine. Figure...

A closer look at the new wave of glaucoma surgery – radical or old school?

1 October 2016 | | Glaucoma
Glaucoma is a challenging condition to treat because the exact pathophysiology remains unclear and the only readily modifiable factor is the intraocular pressure (IOP). Additionally, most glaucoma patients are completely asymptomatic, yet are often subjected to lifelong medical therapy. The...

Management of diabetic macular oedema in vitrectomised eyes

1 August 2016 | | Retina / Uvea / Vitreous
Diabetic macular oedema (DMO) is one of the leading causes of blindness; its prevalence is on the rise with progressive increase in numbers of people suffering from diabetes. The management of DMO has evolved significantly over the past few years....

Improved efficacy expected with second-generation microinvasive glaucoma surgery (MIGS) devices

1 July 2015 | | Glaucoma
Microinvasive surgical approaches to primary open-angle glaucoma (POAG) offer minimally traumatic options for effective intraocular pressure (IOP) reduction in appropriately selected glaucoma patients. Increases in laser trabeculoplasty rates and wider adoption of glaucoma drainage device filtration procedures, together with the...

Clinical and management strategies in glaucoma practice: perspectives from international glaucoma specialists

1 April 2015 | | Glaucoma
Management options and outcomes in glaucoma practice were reviewed at the 7th Moorfields International Glaucoma Symposium, held in London on 24 January 2015. This article summarises perspectives from international glaucoma specialists on debated issues in topical therapy, glaucoma surgery, diagnostic...

Immunoglobulin G4-related ophthalmic disease – what is it? (Part 1)

3 February 2023 | | Ophthalmology
Part 1: Epidemiology, classification, radiology, histopathology and associations (see Part 2 here) In this two-part series, Li Yen Goh reviews IgG4 disease and reminds us of diagnostic challenges faced. Introduction Immunoglobulin G4 (IgG4) disease is a recently recognised idiopathic systemic...

Glaucoma-NET: a novel way of improving glaucoma management in sub-Saharan Africa

1 June 2022 | | Ophthalmology, Cornea / External Eye Disease
Background Glaucoma is the second most common cause of blindness worldwide [1]. People with untreated glaucoma suffer from irreversible, progressive loss of sight. The disease is characterised by progressive loss of visual field, with pathological cupping of the optic disc...