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Transcriptomic analysis of ocular tissues

1 August 2018 | | Glaucoma | Ciliary body, Cornea, Gene expression, Glaucoma, RNA sequencing, Trabecular meshwork, Transcriptome
Transcriptomics is defined as the analysis of the complete set of RNA transcripts present in a cell under different circumstances, quiescent versus challenge, by microarray analysis. Comparison of transcriptomes identifies genes that are differentially expressed in different cell populations under...

Broadening horizons in ophthalmology: crafting a varied elective experience

24 January 2024 | | Ophthalmology, ONLINE EXCLUSIVE ARTICLES
The elective period for medical students is a unique opportunity to immerse oneself in a field of interest. For students interested in ophthalmology, this can offer a dedicated experience for what can otherwise be quite limited through undergraduate rotations. Alongside...
Orbit journal cover image

Subperiosteal abscess management in adolescents and adults

1 September 2023 | | Oculoplastics, Orbit | Adult orbital cellulitis, adult subperiosteal abscess, orbital cellulitis, subperiosteal abscess
This is a retrospective study looking at the clinical and treatment profiles of patients with orbital subperiosteal abscess (SPA) in an adolescent and adult population. SPA is rarer in this age group compared to a paediatric population (less than nine-years-old)...

The importance of ‘hands-on’ learning

1 April 2014 | | AMD, Cataract and Refractive, Cornea / External Eye Disease, Emergency Ophthalmology, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Oculoplastics, Ophthalmology, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous
Providing ongoing professional education and development for the allied professions out of the clinic or hospital setting is often quite challenging. The reorganisation of rotas, heavy clinic lists and financial constraints all add up to making the opportunity to learn...
Eye journal cover image.

Gene therapy: perspectives from young adults with Leber’s congenital amaurosis

5 June 2023 | | Retina / Uvea / Vitreous
The authors present their telephone survey data of 10 patients with a mean age of 24.4 years regarding their opinion on gene therapy for their Leber’s congenital amaurosis. Patients were recruited at the Hospital for Sick Children, Toronto. Of the...
Progress in Retinal and Eye Research.

Comprehensive review of inherited retinal diseases

3 June 2024 | | Retina / Uvea / Vitreous
The authors offer an up-to-date review of inherited retinal diseases (IRDs). In each section the authors discuss the molecular basis of disease, genotype and clinical manifestation. They also discuss the investigation findings and current evidence in the treatment of the...

Immunoglobulin G4-related ophthalmic disease – what is it? (Part 2)

3 April 2023 |
Part 2: Clinical presentation and treatment (see part 1 here) Introduction IgG4-related disease (IgG4-RD) is understood to have a vast clinicopathological spectrum; nearly every organ has had reported involvement. Similarly, IgG4-related ophthalmic disease (IgG4-ROD) is known to affect nearly every...

Emerging developments in dry eye

1 August 2017 | | Cornea / External Eye Disease
An estimated 344 million people worldwide suffer from dry eye [1]. This chronic syndrome is characterised by a vicious cycle of tear film hyperosmolarity, tear instability and corneal stress, leading to increased friction, inflammation, ocular surface damage and decreased visual...

Capacity-strengthening for diabetic retinopathy services in low- and middle-income countries

3 February 2023 | | Ophthalmology
Introduction DR-NET eye health professionals in low- and middle-income countries (LMICs) have, since 2015, been able to access training in diabetic retinopathy (DR) grading provided by Gloucestershire Retinal Education Group (GREG). GREG, led by Professor Peter Scanlon and based at...

The results of the last survey Feb 2020

5 February 2020 | | Ophthalmology, Cataract and Refractive
I appreciate that I keep on reiterating it, but again we see so much practice variance. Who is right and who is wrong? Is there a right or wrong approach? And does it matter? I think it probably does matter....

Ocular Dirofilariasis: a diagnosis on the rise?

1 February 2015 | | Ophthalmology, Cornea / External Eye Disease
Dirofilaria repens is one of 40 species of Dirofilaria. It is a zoonotic filarial nematode that commonly impacts dogs, however, human infection can occur through affected organs like skin, lung and eyes [1]. Although, there have been case reports of...

Macula re-attachment following intravitreal ranibizumab in rhegmatogenous retinal detachment

1 February 2015 | | Ophthalmology, Retina / Uvea / Vitreous
Ranibizumab (Lucentis) is a vascular endothelial growth factor inhibitor (anti-VEGF) used for treatment of choroidal neovascular membrane [1]. We report a case where macula off inferior rhegmatogenous retinal detachment was misdiagnosed as wet age-related macular degeneration (AMD) and three intravitreal...