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In vivo confocal microscopy, principles and use in keratitis Part 1: Principles

In 1968 Maurice introduced the concept of high powered specular microscopy, it was in that very year that the first scanning confocal microscope was proposed. Marvin Minsky developed the first confocal microscope in 1955 named the ‘double focusing scanning microscope’....

Large language models in ophthalmology

Traditional artificial intelligence (AI) models typically require large amounts of labelled data for training. For example, to develop a model capable of detecting macular pathologies on optical coherence tomography scans, thousands of scans would need to be manually labelled by...

Saccadic eye movements in young-onset Parkinson’s disease

The objective of this study was to understand control of saccadic eye movements in patients with young onset Parkinson’s disease (YOPD) where onset of disease symptoms appears early in life (<40 years of age). Functional magnetic resonance imaging (fMRI) was...

Comparison of two visual acuity test versions for different distances in a paediatric population

The authors present the findings of a study which aimed to determine whether using 2 metre and 4 metre retro-illuminated ETDRS charts are comparable in children. Order of testing was standardised (right eye, left eye, binocular), however different charts were...

Incidence and outcomes of endophthalmitis with in-house compounded intravitreal bevacizumab injections

This multicentre study examining a five-year period from 2014 to 2018 evaluated the incidence rate and outcomes of endophthalmitis after intravitreal injection of in-house compounded bevacizumab. In-house compounded syringes were prepared in compounding pharmacy using sterile standard operating guidelines. All...

Changes in the prevalence of myopia in middle-aged caucasian Australians compared to UK biobank

This article compares rates of myopia and high myopia in large cohorts of caucasian Australians from the Busselton Healthy Ageing Study, the urban Gen1 of the Raine Study, the Blue Mountains Eye study and Melbourne Visual Impairment Project. The former...

Comparison of visual acuity testing in clinic versus at home

The authors present a prospective cohort study including children aged three to 12-years-old with and without ocular pathology. Visual acuity was assessed using both an M&S Smart System in clinic, using different protocols depending on the age of the child....

Malpractice from telephone triage in ophthalmology

The authors examined malpractice lawsuits related to ophthalmology telemedicine telephone triage in the US. The study reviewed a total of 510 lawsuits and identified 18 cases that involved synchronous telephone visits, while none involved video telecommunication. The study found that...

Outcomes of reinjection of Ranibizumab for reactivation of retinopathy of prematurity

The authors present their data from Egypt assessing the effects of Ranibizumab reinjection for neonates with retinopathy of prematurity (ROP). Doses given were 0.25mg/0.025mL. They screened 2318 infants with 115 (5%) of infants with a mean post menstrual age (PMA)...

Diabetic retinopathy screening in Belize: a country’s journey towards reducing blindness from DR

The rise of diabetes mellitus (DM) and its complications is a public health concern in the Caribbean. The Caribbean Diabetic Retinopathy (DR) Programme, managed by the London School of Hygiene & Tropical Medicine (LSHTM) and funded by the Queen Elizabeth...

Essentials of OCT in Ocular Disease

Sir Isaac Newton was the first to establish the technique of low coherence white light interferometry. Following on from this, the principle of laser interferometry as an imaging modality for retina was applied by David Huang and his associates in...

Aug/Sep 2018 Quiz

History A seven-year-old girl presented with a presumed papillomatous lesion on right inferior fornix (Figure 1). Her parents said the lesion was increasing in size for two weeks. CT scans (Figure 2) revealed a lesion occupying the right medial canthus....