You searched for "Gene therapy"
Radiotherapy for orbital apex cavernous haemangiomas
This is a review of six patients with cavernous venous malformations (haemangiomas) involving the orbital apex who were treated with fractionated stereotactic radiotherapy. Patients were diagnosed on MRI imaging with only one having had previous surgery to debulk the lesion....
IAC vs. IVC chemotherapy for RB
1 April 2018
| Jonathan Chan
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Paediatric Ophthalmology / Strabismus
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Child health (paediatrics), Neoplasia, Retina, Treatment Medical
This a single centre retrospective review of consecutive patients between 1997 and 2014, of all sporadic unilateral retinoblastoma (RB) group D cases, treated with combined intravenous chemotherapy (IVC) and focal treatments (1997- 2008), or intra-arterial chemotherapy (IAC) treatment (2008 to...
Insights in resistant diabetic macular oedema
5 August 2022
| Sofia Rokerya
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Retina / Uvea / Vitreous
This article gives a bird’s eye review of the different modalities for the treatment of diabetic macular oedema (DME). The debut of anti-VEGFs has brought a paradigm shift in DME management. This treatment has now become a major breakthrough in...
Aflibercept treatment in polypoidal choroidal vasculopathy
1 April 2019
| Sofia Rokerya
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Retina / Uvea / Vitreous
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Aflibercept, Caucasian population, Indocyanine green angiography, Optical coherent tomography, Polypoidal choroidal vasculopathy, Prospective study
The authors present a study to evaluate the anatomical and functional efficacy of aflibercept intravitreal (IVT) as a monotherapy in polypoidal choroidal vasculopathy (PCV) in a Caucasian population treated with initial three-monthly aflibercept IVT, followed by a bimonthly regimen for...
Injection frequency and anatomic outcomes following conversion to Aflibercept in neovascular AMD patients
1 December 2014
| Jonathan Chan
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Retina / Uvea / Vitreous
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Degeneration, Macula, Treatment Medical
This is a retrospective study of patients with neovascular age-related macular degeneration (AMD) treated with intravitreal Lucentis and / or Avastin who were switched to aflibercept (Eylea). This study was carried out by the Casey Eye Institute retinal clinics, between...
Insights from the ‘Rb-NET Challenges’ Session: Evolving approaches in global retinoblastoma management
2 April 2025
| Mattan Arazi, Ido Didi Fabian, Nick Astbury, Brenda Gallie (Prof), Covadonga Bascaran, Marcia Zondervan
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EYE - Paediatrics, EYE - Pathology, EYE - Oncology
The Retinoblastoma Network (Rb-NET) Multidisciplinary Team (MDT) platform, developed by the London School of Hygiene & Tropical Medicine (LSHTM) and Professor Ido Didi Fabian, is a web-based telemedicine initiative that regularly hosts virtual MDT meetings focused on the evaluation and...
Inverted papilloma
This is a retrospective review of 22 patients with inverted papilloma, including nine cases confined to the nasolacrimal system and 13 involving into the orbit. This is a rare disease and the report is the largest published series of periocular...
A review of orbital plasmacytomas
This is a multicentre review of 30 patients with orbital plasmacytomas. There were equal numbers of males and females, and the average age at diagnosis was 57 years. All patients were either already diagnosed with systemic multiple myeloma or it...
Lacrimal gland carcinoma
This is a major review of the management of lacrimal gland carcinoma, focusing mainly on adenoid cystic carcinoma. Relevant literature published in English since 1970 was included amounting to some 40 articles after filtering. Overall mortality for all lacrimal gland...Effective treatment for rare sight-threatening infection
A drug candidate, based on pioneering UCL and Moorfields Eye Hospital research and currently under development by SIFI S.p.A., has been found to be highly effective in treating a rare sight-threatening eye infection in a new international clinical trial.A single intravitreal bevacizumab in the treatment of breast carcinoma related choroidal metastasis
1 June 2015
| Antonio Berarducci, Inderpaul S Sian, Roland Ling
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EYE - Cataract, EYE - Cornea, EYE - General, EYE - Glaucoma, EYE - Imaging, EYE - Neuro-ophthalmology, EYE - Oculoplastic, EYE - Oncology, EYE - Orbit, EYE - Paediatrics, EYE - Pathology, EYE - Refractive, EYE - Strabismus, EYE - Vitreo-Retinal
Case report Choroidal metastasis represents a common form of intraocular malignancies occurring in up to 10% of patients with systemic metastasis [1]. The most common primary sites of ocular metastasis are breast carcinoma in women and lung carcinoma in men,...
