You searched for "choroideal"
Transfected RPE cells inhibit AMD in rats
1 August 2015
| Graham Wallace
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Choroidal neovascularization, Fibulin-5, Retinal pigment epithelium, Transplantation
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...
Aqueous humour cytokine levels in PCV and nAMD
1 April 2015
| Bheemanagouda Patil
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Retina / Uvea / Vitreous
This study looks into the possible roles of various cytokines or growth factors in the pathogenesis of exudative age-related macular degeneration (AMD) by comparing aqueous levels of 14 cytokines between eyes with polypoidal choroidal vasculopathy (PCV) and those with neovascular...
Progression of myopic maculopathy after treatment
1 October 2014
| Sofia Rokerya
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Retina / Uvea / Vitreous
The authors report on a retrospective study carried out to evaluate long-term progression of myopic maculopathy and functional outcome in eyes treated for myopic choroidal neovascularisation (CNV) and in eyes without CNV. Fifty-four myopic eyes of 30 patients were included...
Aflibercept treatment in polypoidal choroidal vasculopathy
1 April 2019
| Sofia Rokerya
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Retina / Uvea / Vitreous
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Aflibercept, Caucasian population, Indocyanine green angiography, Optical coherent tomography, Polypoidal choroidal vasculopathy, Prospective study
The authors present a study to evaluate the anatomical and functional efficacy of aflibercept intravitreal (IVT) as a monotherapy in polypoidal choroidal vasculopathy (PCV) in a Caucasian population treated with initial three-monthly aflibercept IVT, followed by a bimonthly regimen for...
The approach to trabeculectomy postoperative complications
1 August 2016
| Kaivon Pakzad-Vaezi
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EYE - Glaucoma
Performing a trabeculectomy is like giving birth to a baby. It may be traumatic and there is scope for devastating error but once the operation is completed only then does the real work begin. The bleb must be nurtured into...
Cytokine levels in vitreous fluid in patients with pathological myopia
1 April 2020
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
Pathological myopia (PM) is a leading cause of irreversible visual impairment worldwide, and efforts are dedicated to the study of its underlying mechanisms. Axial extension of the eyeball is regulated via a cascade of biochemical molecules that are initiated in...
Changes in drusen and retinal layer volumes prior to CNV development
7 April 2021
| Ed Rule
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Retina / Uvea / Vitreous
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Age-related macular degeneration, Choroidal neovascularisation type, Drusen load, Imaging biomarkers, Retinal layer volumes
This retrospective longitudinal study looked at patients with wet age-related macular degeneration (AMD) in one eye who subsequently developed wet AMD in the fellow eye. The aim was to discover whether drusen characteristics or volumes of retinal layers correlate with...
Effects of blood donation on the physiology of the eye
1 December 2018
| Kurt Spiteri Cornish
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Retina / Uvea / Vitreous
Hypovolaemia is a state of decreased blood volume, the reduction of which reduces tissue perfusion which may in turn lead to cellular hypoxia and end-organ damage. In blood donation, 500ml of blood is collected in ten minutes. This equates to...
A relationship between central serous retinopathy and obstructive sleep apnoea
This prospective study aimed to evaluate a relationship between central serous retinopathy (CSR) and obstructive sleep apnoea (OSA). Twenty-three subjects (six female and 17 male) were diagnosed with CSR and overnight polysonography was performed to record desaturation and apnoeic episodes....Longitudinal findings in children with neurofibromatosis type 1
3 September 2024
| Claire Howard
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Neuro-Ophthalmology
This retrospective chart review evaluates the ophthalmologic findings of children with neurofibromatosis type 1 (NF1). Optic pathway gliomas (OPGs) are the most common tumours found in children with NF1. Findings are compared between eyes with and without optic pathway gliomas...
Stereotactic radiotherapy for polypoidal choroidal vasculopathy
1 August 2015
| Sofia Rokerya
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Retina / Uvea / Vitreous
Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular AMD. It is a disease of choroidal vasculature characterised by abnormal branching vascular network with aneurysmal dilatations (polyps). Features of PCV include pigment epithelial detachments (PED), subretinal fluid (SRF) accumulation and...
Reduced blood flow and age-related macular degeneration
1 August 2014
| Khadijah Basheer
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Retina / Uvea / Vitreous
This was a prospective cross-sectional study assessing changes in blood flow velocity in patients with age-related macular degeneration (AMD) using a retinal function imager. Sixty eyes with wet AMD were compared to 53 control eyes and the average blood flow...