You searched for "disease"
Associations with ocular surface disease in high school children
2 August 2022
| Fiona Rowe (Prof)
|
Paediatric Ophthalmology / Strabismus
The authors aimed to determine the prevalence of ocular surface symptoms in a high school population and to evaluate its association with contact lens wear and other factors. The study had a population of 3240 students. This was a cross-sectional...
Using OCT to screen and monitor Alzheimer’s disease
1 June 2016
| Claire Howard
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Neuro-Ophthalmology
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Macular thickness, mild cognitive impairment, optical coherence tomography, subjective memory complaints
Alzheimer’s disease (AD) is a neurodegenerative illness characterised by progressive decline in cognitive function. AD is the main cause of dementia worldwide. Over recent years researchers have strived to find biomarkers to diagnose AD, particularly in the early stages of...
OCT measurements of eye muscles for Grave’s disease
2 December 2019
| Fiona Rowe (Prof)
|
Paediatric Ophthalmology / Strabismus
The purpose of this study was to use optical coherence tomography (OCT) to assess horizontal rectus muscle thickening in patients with active and inactive Grave’s ophthalmopathy (GO) compared to healthy controls. This was a cross section observation study of rights...
Low dose steroids for ocular dry eye disease in graft vs. host disease
1 August 2018
| Tasmin Berman
|
Cataract and Refractive
This double-masked randomised clinical trial compared the response of dry eye disease (DED) to treatment with topical steroids in patients with and without graft vs. host disease (GVHD). Forty-two patients in a single centre (n=21 with and n=21 without GVHD)...
Exploring the potential of neurodegenerative disease screening within age-related eye disease research
3 August 2023
| Lauren R Hepworth
|
Neuro-Ophthalmology
The authors recruited healthy controls aged between 60 and 75-years-old, previously enrolled into a registry as patients following cataract surgery without age-related macular degeneration (AMD). Exclusion criteria included dense cataract, retinal disease, ocular inflammatory disease, moderate glaucoma, optic neuropathy, cancer,...
Where along the vergence pathway is affected by Parkinson’s Disease?
5 April 2022
| Lauren R Hepworth
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Neuro-Ophthalmology
The authors outlined three hypothesis for the effect Parkinson’s Disease has on blur- and disparity-driven vergence with reference to location within the vergence system that is affected to be tested in this prospective study. The study recruited 14 participants with...
Colour Doppler imaging before and after orbital decompression in thyroid eye disease
2 December 2019
| Rina Bhatt
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Oculoplastics, Orbit
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Color Doppler imaging, orbital decompression, thyroid eye disease
In this prospective, uncontrolled study euthyroid patients with moderate to severe inactive thyroid eye disease underwent colour Doppler imaging before and after orbital decompression. Patients with dysthyroid optic neuropathy, corneal breakdown, systemic disease (diabetes, cerebrovascular accident, cardiovascular and peripheral vascular...
Stem cell therapy for Parkinson’s disease: researching for an effective cure
1 December 2015
| Romina Vuono
|
Neuro-Ophthalmology
Neurodegenerative diseases are characterised by the chronic and progressive loss of neurons, which in turn results in loss of cognitive and physical functions. The World Health Organization has estimated that the disability-adjusted life years lost from neurological disease was about...
Using frequency doubling technology perimetry to identify Alzheimer’s disease early
1 June 2014
| Claire Howard
|
Neuro-Ophthalmology
|
Alzheimer disease, frequency doubling technology, magnocellular pathway, visual field tests
Alzheimer’s disease is widely reported to be associated with deficits in visual function. Visual disturbances include impaired stereopsis, contrast sensitivity and motion detection. Deficits specific to the magnocellular pathway (MGC) have been identified in Alzheimer’s disease. This article compares the...
Idiopathic orbital pseudotumor as first sign of systemic inflammatory disease
4 February 2021
| Fiona Rowe (Prof)
|
Paediatric Ophthalmology / Strabismus
The authors describe four children in whom idiopathic orbital pseudotumor (IOP) was the initial solitary finding with systemic inflammatory disease developing later. Four children were seen over a five-year period. Mean age was 9.75 years (2-14). Three were white and...
A revolution in modern genetic testing for the clinical management of ocular disease
1 August 2016
| Jane Ashworth, Chris Lloyd (Prof), Graeme Black
|
Cataract and Refractive, Cornea / External Eye Disease, Genetics, Glaucoma, Imaging, Neuro-Ophthalmology, Ocular Pathology and Oncology, Ophthalmology, Oculoplastics, Optometry, Orbit, Paediatric Ophthalmology / Strabismus, Retina / Uvea / Vitreous, AMD, Emergency Ophthalmology
Recent years have seen a huge increase in our understanding of the genetic factors underlying a wide variety of eye diseases. This has included common conditions such as glaucoma and age-related macular degeneration, as well as those conditions which have...
Sickle cell eye disease: an overview of vitreoretinal complications and their surgical management
1 December 2016
| Antonio Berarducci, Tom Williamson
|
Retina / Uvea / Vitreous
Sickle cell disease is the most common genetic disorder worldwide and is associated with lifelong anaemia, intermittent pain and multi-organ morbidity. Ocular involvement can be associated with significant visual impairment due to the complications of proliferative sickle retinopathy (PSR). Occasionally...